...Sebastian Gippert; Maik Brune; Daniela Choukair; Markus Bettendorf Introduction: The diagnosis of arginine vasopressin deficiency (AVD, formerly central diabetes insipidus) remains a challenge. In recent years, stimulated copeptin has emerged as a promising tool to diagnose AVD. Methods...

...Christine A. March; Shruti Sastry; Michael J. McPhaul; Sarah E. Wheeler; Luigi Garibaldi Introduction: Stimulated copeptin may provide an alternative to water deprivation testing (WDT) in the evaluation of polyuria-polydipsia syndrome (PPS). Though best studied, arginine stimulation alone produces...

... for patients. Arginine-stimulated copeptin has been shown as a putative parameter for the differential diagnosis of CDI in adults. Methods: In this single-centre retrospective study, we identified paediatric patients with suspected pituitary disorders who underwent standard arginine testing. Patients with CDI...

...Christine A. March; Shruti Sastry; Michael J. McPhaul; Sarah E. Wheeler; Luigi Garibaldi Introduction: Copeptin, co-secreted with arginine vasopressin, is regulated by osmotic and volume stimuli but also responds to intravenous arginine and insulin-induced hypoglycemia. The serum copeptin response...

...Rachel L. Boal; James Hughes; Debbie Matthews; Helen Johnstone; Christopher Boot; Tim D. Cheetham Introduction: Copeptin concentrations are a useful component of the diagnostic workup of paediatric patients with polyuria and polydipsia, but the value of measuring copeptin in patients...

...Brandon Jones; Margarita Corredor; Aida Lteif; Siobhan Pittock; Joshua Bornhorst; Ana Creo Background: Copeptin levels reflect vasopressin activity and help classify osmoregulatory disorders. There is limited pediatric experience using copeptin to diagnose and manage diabetes insipidus, syndrome...