...Shlomit Shalitin Background: In recent years, remarkable advances in cancer immunotherapy have been introduced in the field of oncology. Since the discovery of immune checkpoint inhibitors (ICIs), these groups of medications have become a crucial treatment for several types of adult cancer. Summary...

...Valentina Pampanini; Jasmin Hassan; Elizabeth Oliver; Jan-Bernd Stukenborg; Pauliina Damdimopoulou; Kirsi Jahnukainen The increasing cure rate of cancer has led to a vast population of survivors having to face the late adverse effects of oncological treatments, with fertility impairment being one...

...Zoltan Antal; Sadana Balachandar Survival from childhood cancer has improved dramatically over the last few decades, resulting in an increased need to address the long-term follow-up and care of childhood cancer survivors. Appropriate linear growth is an important measure of health...

...; Primus-E. Mullis; Roland Pfaffle; Lars Sävendahl; Grit Sommer; Muriel Thomas; Sally Tollerfield; Gladys R.J. Zandwijken; Jean-Claude Carel Background: The long-term safety of growth hormone treatment is uncertain. Raised risks of death and certain cancers have been reported inconsistently, based...

...Emelie Benyi; Helle Kieler; Marie Linder; Martin Ritzén; Jan Carlstedt-Duke; Torsten Tuvemo; Otto Westphal; Lars Sävendahl Background/Aim: High-dose oestrogen treatment has been used to reduce growth in tall adolescent girls. The long-term safety with regard to cancer has not been clarified. Our...

...Rena Vassilopoulou-Sellin; Mary Jean Klein; Bartlett D. Moore; Hubert L. Reid; Joann Ater; Hallie A. Zietz We evaluated the growth response of 20 childhood cancer survivors who received growth hormone (GH) replacement therapy (0.3 mg/kg/week) for at least 12 months. In all subjects, GH deficiency...

...Claudine Junien As opposed to dominantly-acting oncogenes, antioncogenes represent a new class of tumor suppressor genes, the prototype of which is the gene for retinoblastoma. Hereditary predisposition to cancer can be due to alteration of one copy of an antioncogene, while a tumor will develop...

... (HOE-766) in adult men with cancer of prostate. The decrease in serum androgen levels is accompanied by objective remission of the cancer in approximately 75% of cases. In a preliminary study where the LHRH agonist was administered in combination with the pure antiandrogen RU-23908, it was shown...

... concentration than did normal breast or tumours from other body sites. No significant difference was found whentumours from testosterone or drostanolone treated patients were studied. Oestrogen Breast Cancer Androgens 21 11 2008 © 1970 S. Karger AG, Basel 1970 Copyright / Drug Dosage...

...John Radford The late effects of chemotherapy and radiation treatment on fertility are an important issue for long-term survivors of cancer who may not have started or completed a family at the time of diagnosis. Attempts at protecting reproductive function using hormonal manipulation have proved...

...Jørn Müller Cancer therapy includes surgery, chemotherapy and irradiation. Depending on the diagnosis, the location of the neoplasm and the age of the patient, these treatment modalities may be given alone or in combination. All forms of cancer therapy can affect the hypothalamic-pituitary-gonadal...

... reported. Epidemiological studies indicate a relationship between high-normal insulin-like growth factor-I levels and cancer development. No definitive answers can presently be given regarding the safety of long-term GH therapy in otherwise healthy individuals during the somatopause. 17 11 2004...

...Charles A. Sklar There have been concerns that growth hormone (GH) therapy may be associated with an increased risk of cancer. Although data are limited and conflicting, one recent report on cancer risk in individuals with no cancer history or risk factors for cancer who were treated with pituitary...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Ghrelin GH secretagogues GH Gastroenteropancreatic functions Food intake Cardiovascular system Cancer Metabolism...