... improvement in glucose handling – mainly, a rise in insulin sensitivity and a decline in plasma insulin-like growth factor I levels. Conclusions: Caloric restriction seems to be the best positive modulator of metabolism to achieve longevity. Other specific metabolic adaptations, even those genetically induced...

... the timing and effect of severe (70% of ad libitum), moderate (50%) and mild caloric restriction (30%) in various species. The most common dietary intervention has been a 50% reduction in caloric intake. The development of disease in adulthood as a consequence of fetal programing was first described...