... Wasagu Idris; Vijayalakshmi Bhatia; Junfen Fu; Gail Goldberg; Lars Sävendahl; Rajesh Khadgawat; Pawel Pludowski; Jane Maddock; Elina Hyppönen; Abiola Oduwole; Emma Frew; Magda Aguiar; Ted Tulchinsky; Gary Butler; Wolfgang Högler Background: Vitamin D and calcium deficiencies are common worldwide, causing...

... processes that include cell proliferation and differentiation as well as hyperplasia and neoplastic transformation. Hypothalamic neurohormones bind specific receptors belonging to the G-protein-coupled receptor superfamily to generate intracellular effectors, in particular cAMP and calcium. Several in vivo...

...Anders Bergenfelz; Bo Ahrén It has been suggested that calcium changes the set point of the pituitary thyroid feedback. It is not known, however, if small and slow changes of calcium and/or parathyroid hormone (PTH) within the physiological range influence the serum levels of thyrotropin (TSH...

...Jean-Louis Wémeau Calcium availability is reduced in the elderly because not only of decreased dietary intake of calcium and vitamin D, but also reduced solar exposure and a decrease in the production of provitamin D by the skin. Moreover, calcitriol synthesis and calcitriol activity on calcium...

...Jean-Yves L. Reginster Several approaches may be suggested for prevention or treatment of senile osteoporosis. In elderly patients, an association of calcium and vitamin D supplementation has been shown to reduce nonvertebral fractures up to 40% over an 18-month period. Calcitonin, given...

...Bo Ahrén; Anders Bergenfelz To study possible influences of a mild increase in serum-ionized calcium concentration that is seen during daily life on circulating parathyroid hormone (PTH) immunoheterogeneity, we used sequence-specific PTH assays to determine serum intact PTH, C-terminal PTH and N...

...Anders Bergenfelz; Bo Ahrén It is not known whether thyroid surgery evokes changes in calcium metabolism. We therefore studied 6 patients operated upon with hemithyroidectomy for benign thyroid diseases, preoperatively and at 3 months and 1 year postoperatively. We measured changes in serum levels...

...Anders Bergenfelz; Stig Valdermarsson; Bo Ahrén Primary hyperparathyroidism (pHPT) is associated with a right-shifted relation between parathyroid hormone (PTH) secretion and calcium. However, it is also possible that a decreased suppressibility of PTH secretion by calcium is important...

...Michel Paillard; Jean-Paul Gardin; Pascale Borensztein; Alain Prigent We studied the effects of acute modifications in plasma calcium on parathormone (PTH) secretion in 23 patients with primary hyperparathyroidism (PHPT). In 12 patients, PTH hypersecretion was autonomous, and basal plasma calcium...

... the mechanisms by which corticotropin exerts its trophic action we have investigated the effects of cycloheximide, calcium and calcium chelator administration on intact and hypophysectomized animals. These substances were injected in rats with or without corticotropin, and slices of adrenal glands from control...

...V. Leclercq-Meyer; J. Marchand; W.J. Malaisse The interrelationship between arginine and calcium in glucagon release was studied using the in vitro perfused rat pancreas. In the presence of a normal 2 m M calcium concentration, 10 m M arginine provoked biphasic glucagon release, the amplitude...

...Willy J. Mahisse; Antonio C. Boschero Nifedipine inhibits calcium-45 net uptake and glucose-induced insulin release in rat pancreatic islets, without affecting glucose oxidation and calcium-45 efflux. These findings are compatible with the view that nifedipine inhibits the entry of calcium in the B...

...G.F. Mazzuoli; A. Scarda; I. Antonozzi; G. Coen Biological assay of human plasma calcitonin extracted by oxycellulose procedure gives an overestimation of hormone titer due to the calcium content of extracts.However, in the range of the extract doses required for thebioassay, calcitonin-like...

...T.V. Gudmundsson; N.J.Y. Woodhouse The regulation of plasma calcium is usually attributed to variations in osteoclastic resorption of bone under the influence of parathyroid hormone. This hormone however increases tubular reabsorption of calcium and absorption of calcium from the gut. The actions...