...Marco Janner; Christoph Saner This paper gives an overview of the impact of type 1 diabetes on bone health in children and adolescents. Firstly, we analyse studies using dual X-ray absorptiometry to assess bone mineral content and bone mineral density. Then, we discuss modern, non-invasive...

...Tania M. Espinosa Reyes; Gisselle Leyva González; Emma Domínguez Alonso; Henrik Falhammar Background: The effects of hyperandrogenism and steroid treatment on bone mineral density (BMD) in patients with congenital adrenal hyperplasia (CAH) are controversial. Objectives: The objectives of this study...

... Royal Children Hospital patients who had been administered at least 1 dose of intravenous ZA from 2002 to 2015 was undertaken. Results: The audit included 309 children with 228 being treated for bone fragility conditions. Of the 228, 68 had height-adjusted lumbar spine bone mineral density Z-scores...

... puberty, and were receiving oral testosterone or oral and then transitioned to intramuscular testosterone, to complete virilization, were included. Prior/concomitant zoledronic acid use was included. The primary outcome was lumbar spine areal bone mineral density (BMD LS). Results: Puberty was induced...

... females of reproductive age. The characteristic features of PCOS individually have opposing effects on bone mineral density (BMD); however, their cumulative effect on BMD has not been clearly defined. Adolescence and young adulthood span a crucial period in achieving peak bone mass. Thus, a better...

...Reeli Tamme; Jaak Jürimäe; Evelin Mäestu; Liina Remmel; Priit Purge; Eva Mengel; Vallo Tillmann Background: Cross-sectional studies have associated serum testosterone with bone mineral density (BMD). However, there is a shortage of prospective longitudinal studies in this domain, leaving it unclear...

... were seen. Laboratory tests revealed normal pubertal basal and GnRH-stimulated gonadotropin levels, normal Sertoli cell markers, and increased testosterone. The prepubertal lumbar spine bone mineral density (BMD) was normal but pubertal bone mineral accrual was incomplete, leading to osteopenia...

... report on the effects of rhGH on bone formation, dual-energy X-ray absorptiometry (DXA) total body (TB) bone mineral density adjusted for height and lumbar spine (LS) bone mineral apparent density (BMAD), and body composition. Methods: Prospective study of 8 children with CD (6 male), aged 14.8 years...

...Christina Wei; Toby Candler; Nikki Davis; Ruth Elson; Nicola Crabtree; Michael Stevens; Elizabeth Crowne Background: Childhood leukaemia survivors treated with haematopoietic stem cell transplantation and total body irradiation (HSCT-TBI) have multiple risk factors for reduced bone mineral density...

..., and review the literature on 9 previously reported cases. Results: Hemizygous male carriers presented with multiple peripheral bone fractures, low bone mineral density (BMD), and vertebral compression fractures. Heterozygous female carriers did not have a history of fragility fractures, although 1 individual...

.... Bone mineral density Fracture Inflammatory bowel disease Duchenne muscular dystrophy Inflammation Glucocorticoid Osteoporosis Acute lymphoblastic leukaemia Skeletal fragility in childhood due to chronic disease is a systemic disorder of abnormal bone growth leading to abnormal bone mass...

..., and bone mineral density (BMD) is high in both girls, which might be directly or indirectly related to leptin resistance. Conclusion: The spectrum of clinical features of LEPR deficiency may be expanded with increased BMD. Future observations in LEPR-deficient subjects should help further unravel the role...

... the Cochrane Collaboration's tool for risk of bias. Results: Ten studies (519 children) were included. Four studies (40%) showed a low risk of bias. All studies investigating lumbar spine areal bone mineral density indicated a significant increase as a result of BP treatment. Most studies observed...

... ghrelin and PYY in addition to leptin are related to bone mineral density (BMD) in adolescent overweight boys (OWB) and normal-weight boys (NWB). Participants and Methods: Fifty- five OWB (BMI >85th percentile) and 154 NWB (BMI <85th percentile) aged 12-16 years participated in this study. Fasting...

... of gluconeogenesis due to mutations of either the G6PC gene (GSD1a) or the SLC37A4 gene (GSD1b). Osteopenia is a known complication of GSD1. Objectives: The aim of this study was to investigate the effects of poor metabolic control and/or use of GSD1-specific treatments on bone mineral density (BMD) and metabolism...

...Inge Roggen; Inge Gies; Jesse Vanbesien; Olivia Louis; Jean De Schepper Aim: To identify disease-related risk factors for an altered bone mineral density (BMD) and geometry at young adulthood in patients with diabetes mellitus type 1 (DM1). Methods: Fifty-six DM1 patients (23 females, 33 males...

...: This cross-sectional study examined 230 prepubertal children with asthma (aged 6–11) who had intermittently used inhaled fluticasone propionate for at least 5 years at a mean daily dose of 200 µg (range: 200–350 µg). Serum osteocalcin, cortisol, and bone mineral density (BMD) of the lumbar spine were...

...Anna-Liisa Parm; Jaak Jürimäe; Meeli Saar; Kristel Pärna; Vallo Tillmann; Katre Maasalu; Inga Neissaar; Toivo Jürimäe Aim: Relationships between change of bone mineral density (BMD) and baseline adipocytokine and ghrelin levels over 12 months in prepubertal rhythmic gymnasts (RG) and age-matched...

...Line Cleemann; Kirsten Holm; Hanne Kobbernagel; Sven O. Skouby; Bent Kristensen; Heidi Smedegaard; Anna-Maria Andersson; Arieh Cohen; Claus H. Gravholt Aims: To evaluate area bone mineral density (aBMD) and volumetric BMD (vBMD) by dual-energy X-ray absorptiometry, and relations to bone markers...

... need to be used in children [ 46,47 ]. The problem of the Z score lies in the fact that it compares the patient with a group of children with the same chronological age which does not necessarily reflect the height or maturity of the individual. Though reference values for bone mineral density against...