... to KCNQ1 , are associated with a cardiac and a beta cell phenotype, and thus, this patient population should be screened for hypoglycemia, particularly in the postprandial state. [email protected] 6 09 2024 7 11 2024 8 01 2025 © 2025 The Author(s). Published by S. Karger AG...

... with hyperinsulinism around the world continue to experience neurological sequelae at high rates, highlighting the importance of early diagnosis and effective treatment. 6 08 2022 7 08 2022 29 11 2022 Pancreas Hypoglycemia Beta cells Infants Insulin Glucose © 2022 S. Karger AG...

... have persistent, mild elevation of plasma ammonia in the range of 60–150 μmol/L (102–255 μg/dL). In addition to expression in pancreatic beta-cells, GDH is highly expressed in the kidney, liver, and brain. Because activation of GDH increases renal, rather than liver, ammonia production, therapies...

... the significant differences between alpha and beta cells, it has been shown that both cells share major similarities [ 44 ]. Recent evidence suggests that alpha cells can transdifferentiate into beta cells [ 45,46,47 ], thus it is important to fully understand how alpha cells develop. After the endocrine...

...Frans C. Schuit Functional, metabolic and molecular studies using purified beta cells (β-cells) have contributed to our understanding how insulin synthesis and release are regulated by glucose. Individual rat islet β-cells are heterogeneous in their threshold sensitivity to glucose, so...

.... To investigate the hypothesis of a primary defect in beta-cell development, we designed a rat model of undernutrition, involving an overall reduction in maternal food intake. In this model, fetuses with intrauterine growth retardation have a decreased beta-cell mass, which persists into adulthood and ultimately...