...–15.81 years) and 16 age-, sex-, and BMI-matched healthy controls (5 M, 11 F; median age 12.83 years, range 5.68–15.07 years). None was on levothyroxine treatment. The exclusion criteria were autoimmune, inflammatory, and infection comorbidities. Patients did not differ significantly from controls...

... molecules bind specific fragments of gluten or the islet self-antigen(s) and present these antigens to antigen-responsive T cells. In an appropriate proinflammatory environment, the autoimmune response results in destruction of the intestinal enterocyte and/or the pancreatic beta cell. Environmental factors...

...Mireia Fonolleda; Marta Murillo; Federico Vázquez; Joan Bel; Marta Vives-Pi Type 1 diabetes (T1D) is a metabolic disease of unknown aetiology that results from the autoimmune destruction of the β-cells. Clinical onset with classic hyperglycaemic symptoms occurs much more frequently in children...

...Maurizio Delvecchio; Maria Felicia Faienza; Antonella Lonero; Vincenzo Rutigliano; Ruggiero Francavilla; Luciano Cavallo Background/Aims: Prolactin (PRL) is produced by the anterior pituitary gland. It exerts its role on the breast gland but also plays a modulatory role in autoimmune mechanisms...

...Elizaveta M. Orlova; Anna M. Bukina; Elvira S. Kuznetsova; Maria A. Kareva; Ekaterina U. Zakharova; Valentina A. Peterkova; Ivan I. Dedov Background: Autoimmune polyglandular syndrome type 1 (APS-1) (OMIM 240300) is a rare autosomal recessive disorder associated with three major manifestations...

..., cases involving autoimmune diseases have not been described. We report a 15-year-old boy with SCAD deficiency who suffered from pernicious anaemia, vitiligo, scleroatrophic lichen and autoimmune thyroiditis. As has been reported in other mitochondrial disorders, we hypothesised that autoimmune diseases...

...Stefano Mariotti; Alessia Prinzis; Mariangela Ghiani; Valentina M. Cambuli; Sabrina Pilia; Valeria Marras; Daniela Carta; Sandro Loche Background: Chronic autoimmune thyroiditis (CAT) displays a strong female predominance with female-to-male (F:M) ratios of 4–20:1 in adults and 2–9:1 in children...

...C. Boitard; J. Timsit; E. Larger; D. Dubois Insulin-dependent diabetes mellitus (IDDM) results from the autoimmune destruction of the endocrine (β) cells responsible for the secretion of insulin. Experimental and human studies have resulted in unpredicted developments over the past ten years...

...A.P. Weetman Like all autoimmune diseases, those affecting the thyroid arise as the result of an interaction between genetic, environmental and endogenous factors. Genes outside the human leukocyte antigen (HLA) complex play a critical role, with recent associations described between a T cell...

... of this phenomenon is still unknown, since, with the exception of primary myxedema, the prevalence of clinically overt thyroid autoimmune diseases is not increased in the elderly. The peculiar link between autoimmune thyroid failure and ageing is also underscored by the high prevalence of subclinical hypothyroidism...

.... It has been reported that the administration of exogenous TNF suppresses the development of diabetes in nonobese diabetic mice, low producers of endogenous TNF. The results suggest that aberrant TNF-α synthesis may contribute to immune dys-regulation thus favoring the development of autoimmune diseases...

... transient hyperthyroidism while the other 4 developed hypothyroidism, persistent however only in 1 case. Our study confirms that rIFN-α-2a frequently induces thyroid autoimmunity. TPO-Ab seems more useful than Tg-Ab in monitoring the immunological response. Thyroid dysfunction (especially hypothyroidism...

..., instructions or products referred to in the content or advertisements. Autoimmunity Graves’ disease Interleukin-2 receptor Carbimazole Early iodine uptake 1 06 1990 14 12 1990 2 12 2008 Horm Res 1991;35:8-12 © 1991S. Karger AG. Basel 0301 - 0 163/91/0351 -0008S2.75/0 Dynamic...

...J.P. Gayno; G. Strauch The pharmacological treatment of Graves’ ophthalmopathy remains unsatisfactory due to the limited efficacy and severe side effects of the available drugs. Ciclosporine, an immunosuppressive drug has recently been used with the aim of controlling the autoimmune process...

...Ricardo Pujol-Borrell; Ian Todd; Marco Londei; Marc Feldmann; Gian Franco Bottazzo Endocrine epithelial cells do not normally express human leukocyte antigen (HLA) class II molecules, but do so in a variety of autoimmune diseases. This finding suggests the hypothesis that such inappropriate class...

...J.M. Brun Juvenile autoimmune polyendocrinopathies are characterized by the coexistence of hypoparathyroidism, chronic candidiasis and adrenal insufficiency. This is in contrast with associated autoimmune endocrine diseases in the adult. Gonadal insufficiency is frequently encountered as well. Some...

...J.P. Dessaint; J.L. Wémeau Primary myxedema and hypothyroid Hashimoto’s disease provide a well-documented example of organ-specific autoimmunity in man. Very slight modifications or increased release of thyroglobulin or thyroid antigens in the circulation may cause the rupture of autotolerance...

.... Autoimmunity Antiparathyroid antibodies Hypoparathyroidism Hormone Res. 16: 304-307 (1982) Idiopathic Hypoparathyroidism and Autoimmunity P. Burckhardt Department of Internal Medicine, University Hospital. Lausanne, Switzerland Key Words. Autoimmunity Antiparathyroid antibodies Hypoparathyroidism...

...Jean-François Bach; Christian Boitard; Jeannine Charreire Insulin-dependent diabetes and autoimmune thyroiditis can be considered as two models for the determination of the link between genetic predisposition, cellular immune responses and development of the disease. The importance of the HLA...

.... In this respect, the interference of nonstimulatory thyroid antibodies and of other autoimmune mechanisms may be of importance. An important clinical implication of thyroid-stimulating immunoglobulin determinations is their value in predicting the relapse of hyperthyroidism in treated patients. This clinical...