... Antiestrogen Osteoporosis Abstract Selective estrogen receptor modulators (SERMs) comprise a group of structur­ ally diverse compounds which are distinguished from estrogens by their ability to interact with the estrogen receptor but to act as either an estrogen agonist or antagonist depending on the target...

... of hormone regulatory elements and to increase transcription of regulated genes. This paper reviews other antiglucocorticosteroid and antiestrogen systems with reference to this hypothesis, and also describes a four-step analysis of the molecular mechanism of antisteroid hormone action at the receptor level...

...J.C. Faye; A. Fargin; A. Valette; F. Bayard Nonsteroidal antiestrogens display antagonistic as well as agonistic properties when compared with estrogens. These observations and studies of their molecular interactions suggest that part of their activity is mediated through estrogen receptor (ER...

...P. Mauvais-Jarvis; F. Kuttenn; A. Gompel This review analyzes recent data from international literature concerning the antiestrogen action of progesterone and progestins at the level of mammary cells in culture from either breast cancer lines or normal breast obtained from reduction mammoplasties...

...R. Nakano; T. Nakayama; M. Iwao Effect of a chemical antiestrogen, cis-clomiphene, on FSH-induced ovarian follicle growth was studied morphometrically in hypophysectomized immature female rats. NIH-FSH-S 12 alone or in combination with cis-clomiphene was injected to hypophysectomized rats...