.... Monozygotic twins Twin-to-twin transfusion syndrome Low birthweight Androstenedione DHEAS Androgens Health-related quality of life Mental health Psychological morbidity Prenatal exposure to nutrient deficiency, for example, due to placental insufficiency, can be associated with severe...

...Walter L. Miller Congenital adrenal hyperplasia (CAH) due to steroid 21-hydroxylase deficiency (21OHD) has a worldwide incidence of 1 in 15–20,000. Affected individuals have adrenal insufficiency and androgen excess; the androgen excess begins during fetal life, typically resulting in 46,XX...

... of our patient revealed elevated 17OHP and androgen levels during the first weeks of life, but values normalized spontaneously. Genetic testing for CYP21A2 mutations was negative. Thus, it remains unsettled whether the transient 17OHP elevation in this baby was due to a drug effect. Conclusion: The HIV...

... congenital adrenal hyperplasia, androgen-secreting tumors, and exogenous exposure to androgen products. We describe the clinical and hormonal features of a series of children who were referred to endocrine evaluation due to premature pubarche. Methods: This is a retrospective case series study of 14 children...

... 25247652 1421-7082 6. Bhasin   S , Cunningham   GR , Hayes   FJ , Matsumoto   AM , Snyder   PJ , Swerdloff   RS , et al. ; Task Force, Endocrine Society . Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline . J...

...Cornelis J. de Groot; Adriaan van den Berg; Bart E.P.B. Ballieux; Herman M. Kroon; Edmond H.H.M. Rings; Jan M. Wit; Erica L.T. van den Akker Background: Childhood obesity is associated with advanced bone age (BA). Previous studies suggest that androgens, oestrogens, sex hormone-binding globulin...

... to affect androgen synthesis by LCs in cosmetics and children's toys in Europe, some of them are still used in the manufacturing of various goods in many countries outside Europe. The ability of these compounds to leach during hemodialysis and exchange blood transfusions is another potential source...

... and at the time pQCT androgen levels were measured. Results: In males the mean standard deviation (SD) score for trabecular BMD (-0.33 ± 0.71) was reduced, whereas mean cortical BMD (1.05 ± 1.11) was elevated. Mean total (0.86 ± 1.12) and medullary cross-sectional area (CSA; 1.12 ± 1.17) were significantly...

... in development of function-promoting anabolic therapies. At present, androgens and myostatin inhibitors are the two leading classes of function-promoting anabolic therapies that are the most advanced in the drug development process. However, clinical development has been slowed by vexing trial design issues...

...Ruchi Mathur; Glenn D. Braunstein Gynecomastia is common in adolescents and adults, and reflects an underlying imbalance in hormonal physiology in which there is an increase in estrogen action relative to androgen action at the breast tissue level. Most patients have persistent pubertal...

...Jens O.L. Jørgensen; Nina Vahl; Tony B. Hansen; Sanne Fisker; Claus Hagen; Jens S. Christiansen The secretion of both growth hormone (GH) and androgens declines with age which may play a role in the senescent changes in body composition and organ function. Among healthy adults abdominal adiposity...

... resistance, which can be confused with thyrotoxicosis. By constrast, the effects of androgens are controversial. In many patients with hirsutism, SHBG concentrations are low and correlate negatively with both body mass index and fasting insulin levels. Because of the inhibitory effect of both insulin...

...Dirk Vanderschueren Androgens are needed during the entire lifespan of the male skeleton -at least in the rat. Indeed, in aged nongrowing male rats, androgens are necessary for the maintenance of skeletal integrity. In these animals, androgen deficiency results in a menopause-like acceleration...

... (IGF-I) levels, and reduced adrenal androgen secretion. Insulin resistance and glucose intolerance also accompany male ageing. The mechanisms of these age-related changes are still unknown. There are preliminary results on the effects of hormonal replacement therapy in older males with mild...

... acquired immunodeficiency syndrome (AIDS; group B). Controls were sick non-AIDS patients admitted to an intensive care unit (ICU) and healthy volunteers. In groups A and B and the ICU controls, there was a reduction in the excretion of adrenal androgen metabolites and a reduced ratio of 5α to 5β androgen...

... of KDG which appears to antagonize the suppressive action of EE on gonadotropin release. The rapid decrease in the androgen levels seems to be due to a direct inhibitory action of the pill on ovarian and adrenal steroid biosynthesis. 20 10 1994 6 01 1995 5 12 2008 © 1995 S. Karger...

..., but postnatal age must be considered when interpreting the testosterone response when HCG stimulation is used as a diagnostic test. Androgen insensitivity is also a common cause of MPH; the specific defect in androgen receptor function is currently the subject of intense study, using a combination...

... as they are metabolized in the same way as endogenous testosterone. In addition, it appears that recommended doses for replacement therapy are lower than previously suggested. An ideal formulation of testosterone for use in androgen replacement therapy is not currently available. 3 12 2008 © 1992 S. Karger AG...

... higher than 0.85 had A-BFD. Compared to controls, women with PCOS had higher LH, androgen and estrogen concentrations. In both PCOS and controls there were no differences in sex hormone levels between women with different patterns of fat distribution, except androstenedione, which levels were...

...C. Sultan; R. Medlej; C. Chevalier; J.M. Lobaccaro Hyperandrogenism in adolescent girls can be a troubling problem because of the difficulty in establishing a diagnosis and in prescribing appropriate therapy. Androgen excess in adolescent patients encompasses a spectrum of clinical presentations...