...Diana-Alexandra Ertl; Jiajia Chen; Andreas Gleiss; Dominik Janu; Susanne Sagmeister; Adalbert Raimann; Stefan Riedl; Gabriele Haeusler Background: The acid-labile subunit (ALS) is a crucial factor in the tertiary complex. IGF-I and IGFBP-3 are routinely measured during the diagnostic work-up...

..., and the increased expression of IGF-binding proteins (IGFBP)-1 and IGFBP-2, which inhibit IGF-I, in the placenta of SGA neonates. These observations suggest a decreased bioactivity of IGF-I in utero. IGF-I levels remain reduced in SGA children with short stature, as well as IGFBP-3 and acid-labile subunit levels...

...J.S. Renes; J. van Doorn; P.E. Breukhoven; A.J. Lem; M.A.J. de Ridder; A.C.S. Hokken-Koelega Aims: To determine acid-labile subunit (ALS) levels in short small for gestational age (SGA) children and to assess the relationship between ALS levels and several clinical and laboratory characteristics...

...Anna Grandone; Emanuele Miraglia del Giudice; Grazia Cirillo; Ciro Abbondanza; Michele Cioffi; Tiziana Romano; Flora Micillo; Pierluigi Marzuillo; Laura Perrone Background: Homozygous mutations in acid-labile subunit (IGFALS) gene result in short stature, very low circulating levels of acid-labile...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Acid-labile subunit IGFALS gene...

...Felix Schreiner; Stefan Schoenberger; Bernhard Koester; Horacio M. Domené; Joachim Woelfle We report a novel missense mutation p.T145K in the insulin-like growth factor (IGF) acid-labile subunit ( IGFALS ) gene identified in a Turkish patient with normal growth, transient pancytopenic episodes...

.... Growth hormone GH/IGF-1 axis Growth disorders IGF-1 Growth hormone receptor GH1 gene Genetics STAT5B Acid-labile subunit In approximately 80% of children who are referred to a pediatric clinic because of short stature, no definite cause can be established, even after a thorough...

...A. David; S.J. Rose; F. Miraki-Moud; L.A. Metherell; M.O. Savage; A.J.L. Clark; C. Camacho-Hübner Background/Aims: Mutations in the acid-labile subunit (ALS) gene (IGFALS) have been associated with circulating insulin-like growth factor I (IGF-I) deficiency and short stature. Whether severe...

... with the insulin-like growth factor binding protein (IGFBP)-3 or IGFBP-5, and an acid-labile subunit (ALS). The function of ALS is to prolong the half-life of the IGF-I-IGFBP-3/IGFBP-5 binary complexes. Fourteen different mutations of the human IGFALS gene have been identified in 17 patients, suggesting that ALS...

...Robert C. Baxter The actions and bioavailability of the insulin-like growth factors (IGFs) are regulated by a family of six IGF binding proteins. IGFBP-3, the major circulating IGFBP, is unique in combining with a glycoprotein, the acid-labile subunit (ALS), to form a ternary complex with IGF-I...

...Horacio M. Domené; Alicia S. Martínez; Jan Frystyk; Sonia V. Bengolea; María G. Ropelato; Paula A. Scaglia; Jian-Wen Chen; Carsten Heuck; Ole D. Wolthers; Juan J. Heinrich; Héctor G. Jasper Background: In a recently described patient with acid-labile subunit (ALS) deficiency, the inability to form...

...Catherine A. Lissett; Helena Gleeson; Stephen M. Shalet The insulin-like growth factor I (IGF-I) generation test has the potential to assess the ability of an individual to respond to an acute bolus of growth hormone (GH), in terms of IGF-I, IGF-binding protein 3 and acid-labile subunit responses...

... than other possible markers, such as IGF-binding protein 3 (IGFBP-3) and the acid-labile subunit (ALS). Accurate age-matched normative data are essential to give patient data diagnostic meaning. Such data are assay specific and must exclude those individuals with certain confounding medical conditions...

... dosage during the 2nd year of therapy as compared with group A (p < 0.02). Significant increases in insulin-like growth factor I (p < 0.0001), acid-labile subunit (p < 0.0002), and bone/chronological age ratio (p < 0.0001) were found after the 1st year of GH therapy, but no significant...

...René K. Støving; Jørgen Hangaard; Claus Hagen; Allan Flyvbjerg Background/Aim: In healthy adults, serum insulin-like growth factor I (IGF), IGF-binding protein 3 (IGFBP-3), and acid-labile subunit (ALS) form a 150-kD ternary complex under the control of growth hormone (GH). Circulating IGF-I half...