Aim: A new method (BX AHP) for adult height prediction (AHP), based on automated bone age (BoneXpert®, here called autBA) assessment, has been developed and validated. The aim of this study was to evaluate the performance of autBA and BX AHP in comparison with manual Greulich-Pyle bone age (manBA) and Bayley-Pinneau AHP (BP AHP) in children with untreated idiopathic short stature (ISS; including familial short stature and constitutional delay of growth and puberty). Materials and Methods: We acquired the adult height of 190 patients (123 boys and 67 girls) with ISS and 448 (303 male and 135 female) X-rays of their left hand. Results: Mean adult height was 168 ± 6 cm for boys and 155 ± 7 cm for girls. The root mean square error of AHP using BP AHP was 6.35 cm for boys and 4.55 cm for girls. BX AHP using autBA achieved 4.71 cm for boys (p = 0.0013) and 3.72 cm for girls (0.04); including parent’s height improved its root mean square error to 4.46 cm (0.0001) for boys and 3.35 cm (0.02) for girls. Conclusion: The new AHP model performed significantly better than the BP AHP model. Including parental height further improved the performance of AHP.

Greulich WW, Pyle SI: Radiographic Atlas of the Skeletal Development of the Hand and Wrist, ed 2. Palo Alto, Stanford University Press, 1959.
Tanner JM, Whitehouse RH, Healy MJR: A New System for Estimating Skeletal Maturity from the Hand and Wrist, with Standards Derived from a Study of 2,600 Healthy British Children. II. The Scoring System. Paris, International Children’s Centre, 1962.
Roche A, Chumlea C, Thiessen D: Assessing the Skeletal Maturity of the Hand-Wrist: Fels Method. Springfield, Thomas, 1988.
Bayley N, Pinneau SR: Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards. J Pediatr 1952;40:423–441.
Tanner JM, Whitehouse RH, Marshall WA, Carter BS: Prediction of adult height from height, bone age, and occurrence of menarche, at ages 4 to 16 with allowance for midparent height. Arch Dis Child 1975;50:14–26.
Wit JM: Definition and subcategorization of idiopathic short stature: between consensus and controversy. Horm Res Paediatr 2011;76(suppl 3):3–6.
Tanner J, Landt K, Cameron N, Carter B, Patel J: Prediction of Adult height from height and Bone age in childhood. A new system of equations (TW Mark II) based on a sample including very tall and very short children. Arch Dis Childh 1983;58:767–776.
Price DA: Spontaneous adult height in patients with idiopathic short stature. Horm Res 1996;45(suppl 2):59–63.
Martin DD, Deusch D, Schweizer R, Binder G, Thodberg HH, Ranke MB: Clinical application of automated Greulich-Pyle bone age determination in children with short stature. Pediatr Radiol 2009;39:598–607.
Martin DD WJ, Hochberg Z, Sävendahl L, van Rijn RR, Fricke O, Cameron N, Caliebe J, Hertel T, Kiepe D, Albertsson-Wikland K, Thodberg HH, Binder G, Ranke MB: The use of bone age in clinical practice. Part 1. Horm Res Pediatr 2011;76:1–9.
Thodberg HH, Kreiborg S, Juul A, Pedersen KD: The BoneXpert method for automated determination of skeletal maturity. IEEE Trans Med Imaging 2009;28:52–66.
Thodberg HH, Jenni OG, Caflisch J, Ranke MB, Martin DD: Prediction of adult height based on automated determination of bone age. J Clin Endocrinol Metab 2009;94:4868–4874.
Thodberg HH, Neuhof J, Ranke MB, Jenni OG, Martin DD: Validation of bone age methods by their ability to predict adult height. Horm Res Paediatr 2010;74:15–22.
Ranke MB: Towards a consensus on the definition of idiopathic short stature. Horm Res 1996;45(suppl 2):64–66.
Cohen P, Rogol AD, Deal CL, Saenger P, Reiter EO, Ross JL, et al: Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop. J Clin Endocrinol Metab 2008;93:4210–4217.
Prader A, Largo RH, Molinari L, Issler C: Physical growth of Swiss children from birth to 20 years of age. First Zurich longitudinal study of growth and development. Helv Paediatr Acta 1989;52(suppl):1–125.
Armitage P, Berry G, Matthews JNS: Statistical Methods in Medical Research. New York, Wiley Online Library Ebooks Corporation, 1994.
Ranke MB, Grauer ML, Kistner K, Blum WF, Wollmann HA: Spontaneous adult height in idiopathic short stature. Horm Res 1995;44:152–157.
Volta C, Ghizzoni L, Buono T, Ferrari F, Virdis R, Bernasconi S: Final height in a group of untreated children with constitutional growth delay. Helv Paediatr Acta 1988;43:171–176.
LaFranchi S, Hanna CE, Mandel SH: Constitutional delay of growth: expected versus final adult height. Pediatrics 1991;87:82–87.
Sperlich M, Butenandt O, Schwarz HP: Final height and predicted height in boys with untreated constitutional growth delay. Eur J Pediatr 1995;154:627–632.
Rekers-Mombarg LT, Wit JM, Massa GG, Ranke MB, Buckler JM, Butenandt O, et al: Spontaneous growth in idiopathic short stature. European Study Group. Arch Dis Child 1996;75:175–180.
Brämswig J, Fasse M, Holthoff M-L, Lengerke JV, Petrykowski WV, Schellong G: Adult height in boys and girls with untreated short stature and constitutional delay of growth and puberty: accuracy of five different methods of height prediction. J Pediatr 1990;117:886–891.
Maes M, Vandeweghe M, Caju MD, Ernould C, Bourguignon JP, Massa G: A valuable improvement of adult height prediction methods in short normal children. Horm Res 1997;48:184–190.
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