Background: To explore the relationship between magnetic resonance imaging (MRI) findings and multiple pituitary-target hormones in patients with panhypopituitarism or multiple pituitary hormone deficiency (MPHD). Methods: 125 patients with MPHD (102 boys, MPHD group) and 90 age-, sex- and Tanner stage-matched normal children (control group) were enrolled. 96 of the patients with MPHD underwent MRI scans of the hypothalamic-pituitary area. The patients were subdivided into five stages according to their MRI findings. The serum concentrations of GH, IGF-1, FT4, TSH, ACTH, cortisol, FSH, LH, prolactin, testosterone and estradiol were measured in patients and in controls. Results: MRI stage was significantly positively correlated with the number of pituitary hormone deficiencies (r = 0.9, p < 0.001). MRI stage was negatively correlated with peak GH, IGF-1, FT4, cortisol and anterior pituitary height (r = –0.43, –0.47, –0.67, –0.54, and –0.49, respectively, p < 0.01). Diabetes insipidus patients could be stratified according to their MRI stage; diabetes insipidus was found mainly in patients with absence of the posterior pituitary bright spot or small ectopic posterior pituitary bright spot on MRI. Conclusion: An abnormal MRI finding is evidence of MPHD and, correspondingly, there is a noteworthy correlation between MRI and pituitary function.

Tauber M, Chevrel J, Diene G, Moulin P, Jouret B, Oliver I, Pienkowski C, Sevely A: Long-term evaluation of endocrine disorders and effect of GH therapy in 35 patients with pituitary stalk interruption syndrome. Horm Res 2005;64:266–273.
Van Tijn DA, de Vijlder JJ, Vulsma T: Role of the thyrotropin-releasing hormone stimulation test in diagnosis of congenital central hypothyroidism in infants. J Clin Endocrinol Metab 2008;93:378–379.
Rottembourg D, Linglart A, Adamsbaum C, Lahlou N, Teinturier C, Bougnères P, Carel JC: Gonadotrophic status in adolescents with pituitary stalk interruption syndrome. Clin Endocrinol (Oxf) 2008;69:105–111.
Li G-M, Sun X-J, Shao P: Postoperative pituitary hormonal disturbances and hormone replacement therapy time and dosage in children with craniopharyngiomas. Chin Med J 2008;121:2077–2082.
Argyropoulou MI, Kiortsis DN: MRI of the hypothalamic-pituitary axis in children. Pediatr Radiol 2005;35:1045–1055.
Bressani N, di Natale B, Pellini C, Triulzi F, Scotti G, Chiumello G: Evidence of morphological and functional abnormalities in the hypothalamus of growth-hormone-deficient children: a combined magnetic resonance imaging and endocrine study. Horm Res 1990;34:189–112.
Tillmann V, Tang VW, Price DA, Hughes DG, Wright NB, Clayton PE: Magnetic resonance imaging of the hypothalamic-pituitary axis in the diagnosis of growth hormone deficiency. J Pediatr Endocrinol Metab 2000;13:1577–1583.
Bozzola M, Mengarda F, Sartirana P, Tatò L, Chaussain JL Bozzola M, Mengarda F, Sartirana P, Tatò L, Chaussain JL: Long-term follow-up evaluation of magnetic resonance imaging in the prognosis of permanent GH deficiency. Eur J Endocrinol 2000;143:493–496.
Maghnie M, Strigazzi C, Tinelli C, Autelli M, Cisternino M, Loche S, Severi F: Growth hormone deficiency of childhood onset: reassessment of growth hormone status and evaluation of the predictive criteria for permanent growth hormone deficiency in young adults. J Clin Endocrinol Metab 1999;84:1324–1328.
Leger J, Velasquez A, Garel C, Hassan M, Czernichow P: Thickened pituitary stalk on magnetic resonance imaging in children with central diabetes insipidus. J Clin Endocrinol Metab 1999;84:1954–1960.
Gibney J, Johannsson G: Long-term monitoring of insulin-like growth factor-1 in adult growth hormone deficiency: a critical appraisal. Horm Res 2004;62(suppl 1):66–72.
Gibney J, Wolthers T, Johannsson G, Umpleby AM, Ho KK: Growth hormone and testosterone interact positively to enhance protein and energy metabolism in hypopituitary men. Am J Physiol 2005;289:E266–E271.
Giavoli C, Porretti S, Ferrante E, Cappiello V, Ronchi CL, Travaglini P, Epaminonda P, Arosio M, Beck-Peccoz P: Recombinant hGH replacement therapy and the hypothalamus pituitary thyroid axis in children with GH deficiency: when should we be concerned about the occurrence of central hypothyroidism? Clin Endocrinol (Oxf) 2003;59:806–810.
Giavoli C, Bergamaschi S, Ferrante E, Ronchi CL, Lania AG, Rusconi R, Spada A, Beck-Peccoz P: Effect of growth hormone deficiency and recombinant hGH replacement on the hypothalamic-pituitary-adrenal axis in children with idiopathic isolated growth hormone deficiency. Clin Endocrinol (Oxf) 2008;68:247–251.
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