Aim: It was the aim of this study to evaluate adult height (AH) and different methods used for estimation of target height (TH) in children with idiopathic short stature (ISS). Methods: Eighty-five ISS children (36 female, 49 male) were followed until AH was evaluated retrospectively. TH was calculated according to the following 4 methods: (1) as ±6.5 cm to the mean parental heights for boys or girls, respectively, (2) as the mean standard deviation score (SDS) of the parents’ heights, (3) as the sum of the SDS of the parents’ heights divided by 1.61, and (4) as the mean SDS of the parents’ heights multiplied by 0.72. ISS was classified as familial short stature (FSS) if the height was within the TH range and as nonfamilial short stature (NFSS) if it was below the TH range. Results: The number of FSS and NFSS children differed by the method chosen. The mean AH SDS was lower than the TH SDS in FSS in all methods, except in method 3. NFSS children did not attain their TH in either of the methods. Conclusions: Classification of ISS depends on the method of the TH range chosen. ISS children reach a mean AH SDS lower than the mean TH SDS. Only FSS children classified by method 3 reached a mean AH SDS close to the mean TH SDS.

1.
Wit JM, Clayton PE, Rogol AD, Savage MO, Saenger PH, Cohen P: Idiopathic short stature: definition, epidemiology, and diagnostic evaluation. Growth Horm IGF Res 2008;18:89–110.
2.
Ranke MB: Towards a consensus on the definition of idiopathic short stature. Horm Res 1996;45:64–66.
3.
Tanner JM, Goldstein H, Whitehouse RH: Standards for children’s height at age 2–9 years allowing for height of parents. Arch Dis Child 1970;45:755–762.
4.
Tanner JM: Use and abuse of growth standards; in Falkner F, Tanner JM (eds): Human Growth, ed 2. New York, Plenum Press, 1986, vol 3, pp 95–109.
5.
Cole TJ: Galton’s midparent height revisited. Ann Hum Biol 2000;27:401–405.
6.
Cole TJ: Some questions about how growth standards are used. Horm Res 1996;45:18–23.
7.
Hermanussen M, Cole J: The calculation of target height reconsidered. Horm Res 2003;59:180–183.
8.
Darendeliler F, Karaböcüoğlu M, Bundak R, Günöz H, Molzan J, Saka N, Neyzi O: Sitting height and sitting height/height ratio in prepubertal Turkish children (abstract book). 5th Int Congr Auxology, Madrid, 15–19 September, 1991, p 122.
9.
Greulich WW, Pyle SI: Radiographic Atlas of Skeletal Development of the Hand and Wrist, ed 2. Stanford, Stanford University Press, 1959.
10.
Neyzi O, Furman A, Bundak R, Gunoz H, Darendeliler F, Bas F: Growth references for Turkish children aged 6 to 18 years. Acta Paediatr 2006;95:1635–1641.
11.
Neyzi O, Binyildiz P, Alp H: Growth standards for Turkish children. Courrier 1979;29:553–555.
12.
Tanner JM: Recording adolescent physical changes: Tanner system. Del Med J 1973;45:84–88.
13.
Arrigo T, Cisternino M, de Luca F, Saggese G, Messina MF, Pasquino AM, de Sanctis V: Final height outcome in both untreated and testosterone-treated boys with constitutional delay of growth and puberty. J Pediatr Endocrinol Metab 1996;9:511–517.
14.
Volta C, Ghizzoni L, Buono T, Ferrari F, Virdis R, Bernasconi S: Final height in a group of untreated children with constitutional growth delay. Helv Paediatr Acta 1988;43:171–176.
15.
Albanese A, Stanhope R: Does constitutional delayed puberty cause segmental disproportion and short stature? Eur J Pediatr 1993;152:293–296.
16.
LaFranchi S, Hanna CE, Mandel SH: Constitutional delay of growth: expected versus final adult height. Pediatrics 1991;87:82–87.
17.
Rekers-Mombarg LT, Wit JM, Massa GG, Ranke MB, Buckler JM, Butenandt O, Chaussain JL, Frisch H, Leiberman E: Spontaneous growth in idiopathic short stature. European Study Group. Arch Dis Child 1996;75:175–180.
18.
Ranke MB, Grauer ML, Kistner K, Blum WF, Wollmann HA: Spontaneous adult height in idiopathic short stature. Horm Res 1995;44:152–157.
19.
Brämswig JH, Fasse M, Holthoff ML, von Lengerke HJ, von Petrykowski W, Schellong G: Adult height in boys and girls with untreated short stature and constitutional delay of growth and puberty: accuracy of five different methods of height prediction. J Pediatr 1990;117:886–891.
20.
Wit JM: Idiopathic short stature: reflections on its definition and spontaneous growth. Horm Res 2007;67:50–57.
21.
Clayton PE, Gill MS: Normal growth and its endocrine control; in Brook CD, Hindmarsh PC (eds): Clinical Pediatric Endocrinology, ed 4. Oxford, Blackwell Science, 2001, vol 8, pp 95–114.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.