Background: Several endocrine disorders that affect humans also occur as endocrinopathies in companion animals. Spontaneous endocrine disorders in animals may provide valuable information for their counterparts in human endocrinology. For example, the discovery of progesterone-induced growth hormone production in the mammary gland of dogs may have important consequences for understanding the pathogenesis of breast cancer in women. In addition, the majority of diabetic cats have a type of diabetes mellitus that closely resembles type 2 diabetes mellitus in humans and therefore may serve as an animal model for this disease in humans. This review describes several endocrine diseases in companion animals that are quite similar to those in humans and emphasizes their usefulness as spontaneous animal models for human endocrine disorders.

Tan CP, Sano H, Iwaasa H, Pan J, Sailer AW, Hreniuk DL, Feighner SD, Palyha OC, Pong SS, Figueroa DJ, Austin CP, Jiang MM, Yu H, Ito J, Ito M, Guan XM, MacNeil DJ, Kanatani A, Van der Ploeg LH, Howard AD: Melanin-concentrating hormone receptor subtypes 1 and 2: species-specific gene expression. Genomics 2002;79:785–792.
Dackowski WR, Luderer HF, Manavalan P, Bukanov NO, Russo RJ, Roberts BL, Klinger KW, Ibraghimov-Beskrovnaya O: Canine PKD1 is a single-copy gene: genomic organization and comparative analysis. Genomics 2002;80:105–112.
Kooistra HS, Voorhout G, Mol JA, Rijnberk A: Combined pituitary hormone deficiency in German shepherd dogs with dwarfism. Domest Anim Endocrinol 2000;19:177–190.
Pfaeffle RW, Savage JJ, Hunter CS, Palme C, Ahlmann M, Kumar P, Bellone J, Schoenau E, Korsch E, Brämswig JH, Stobbe HM, Blum WF, Rhodes SJ: Four novel mutations of the LHX3 gene cause combined pituitary hormone deficiencies with or without limited neck rotation. J Clin Endocrinol Metab 2007;92:1909–1919.
Fracassi F, Gandini G, Diana A, Preziosi R, Van den Ingh TSGAM, Famigli Bergamini P, Kooistra HS: Acromegaly due to a somatotroph adenoma in a dog. Domest Anim Endocrinol 2007;32:43–54.
Selman PJ, Mol JA, Rutteman GR, van Garderen E, Rijnberk A: Progestin-induced growth hormone excess in the dog originates in the mammary gland. Endocrinology 1994;134:287–292.
Mol JA, Selman PJ, Sprang EP, van Neck JW, Oosterlaken-Dijksterhuis MA: The role of progestins, insulin-like growth factor (IGF) and IGF-binding proteins in the normal and neoplastic mammary gland of the bitch: a review. J Reprod Fertil 1997;51(suppl):339–344.
Mol JA, Lantinga-van Leeuwen IS, van Garderen E, Selman PJ, Oosterlaken-Dijksterhuis MA, Schalken JA, Rijnberk A: Mammary growth hormone and tumorigenesis – lessons from the dog. Vet Q 1999;21:111–115.
Kooistra HS, Den Hertog E, Okkens AC, Mol JA, Rijnberk A: Pulsatile secretion pattern of growth hormone during the luteal phase and mid-anoestrus in beagle bitches. J Reprod Fertil 2000;119:217–222.
Mol JA, van Garderen E, Selman PJ, Wolfswinkel J, Rijnberk A, Rutteman GR: Growth hormone mRNA in mammary gland tumors of dogs and cats. J Clin Invest 1995;95:2028–2034.
Mol JA, Henzen-Logmans SC, Hageman P, Misdorp W, Blankenstein MA, Rijnberk A: Expression of the gene encoding growth hormone in the human mammary gland. J Clin Endocrinol Metab 1995;80:3094–3096.
Emerman JT, Leahy M, Gout PW, Bruchovsky N: Elevated growth hormone levels in sera from breast cancer patients. Horm Metab Res 1985;17:421–424.
O’Brien TD: Pathogenesis of feline diabetes mellitus. Mol Cell Endocrinol 2002;197:213–219.
Slingerland LI, Vasilova VV, Plantinga EA, Kooistra HS, Beynen AC: Indoor confinement and physical inactivity rather than the proportion of dry food are risk factors in the development of feline type 2 diabetes mellitus. Vet J 2008; in press.
Meij BP, van der Vlugt-Meijer RH , van den Ingh TS, Rijnberk A: Somatotroph and corticotroph pituitary adenoma (double adenoma) in a cat with diabetes mellitus and hyperadrenocorticism. J Comp Pathol 2004;130:209–215.
Javadi S, Djajadiningrat-Laanen S, Kooistra HS, Van Dongen AM, Voorhout G, Van Sluijs FJ, Van den Ingh TSGAM, Boer WH, Rijnberk A: Primary hyperaldosteronism, a mediator of progressive renal disease in cats. Domest Anim Endocrinol 2005;28:85–104.
Djajadiningrat-Laanen SC, Galac S, Cammelbeeck SE, Van Laar K, Boer P, Kooistra HS: Urinary aldosterone to creatinine ratio before and after suppression with oral salt or fludrocortisone acetate in cats. J Vet Int Med 2008; accepted.
Galac S, Kooistra HS, Voorhout G, Van den Ingh TSGAM, Mol JA, Van Den Berg G, Meij BP: Hyperadrenocorticism in a dog due to ectopic secretion of adrenocorticotropic hormone. Domest Anim Endocrinol 2005;28:338–348.
Galac S, Kars VJ, Voorhout G, Mol JA, Kooistra HS: ACTH-independent hyperadrenocorticism due to food-dependent hypercortisolaemia in a dog: a case report. Vet J 2008;177:141–143.
Verschueren CP, Rutteman GR, Vos JH, Van Dijk JE, de Bruin TW: Thyrotrophin receptors in normal and neoplastic (primary and metastatic) canine thyroid tissue. J Endocrinol 1992;132:461–468.
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