Background/Aim: Therapy for idiopathic reactive hypoglycemia is ineffective and impractical. Acarbose, an α-glucosidase inhibitor, decreases the absorbed glucose load. This study was done to determine the efficacy of acarbose in this syndrome. Methods: Six patients with symptoms suggestive of postprandial hypoglycemia were chosen consecutively. Three-hour oral glucose tolerance tests using 75 g of glucose were done on each patient. The patients were then treated with acarbose with each meal. Results: All patients had symptomatic hypoglycemia during testing. After 4 weeks of acarbose therapy, all patients were asymptomatic on a regular diet. Conclusion: Acarbose is efficacious in the management of idiopathic reactive hypoglycemia.

Cryer PE: Hypoglycemia – Pathophysiology, Diagnosis, and Treatment. New York, Oxford University Press, 1997, pp 151–153.
Service FJ: Hypoglycemic disorders. N Engl J Med 1995;332:1144–1152.
Tamburrano G, Leonetti F, Sbraccia P, Giaccari A, Locuratolo N, Lala A: Increased insulin sensitivity in patients with idiopathic reactive hypoglycemia. J Clin Endocrinol Metab 1989;69:885–890.
Ozgen AG, Hamulu F, Bayraktar F, Centinkalp S, Yilmaz C, Tuzun M, Kabalak T: Long-term treatment with acarbose for the treatment of reactive hypoglycemia. Eat Weight Disord 1998;3:136–140.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.