Hypocalcemic cardiomyopathy due to hypoparathyroidism is a very rare condition which is usually refractory to conventional treatment for cardiac failure but which responds favorably to restoration of normocalcemia. A 55-year-old man and a 46-year-old woman with a history of postoperative hypoparathyroidism presented with symptoms of cardiac failure and hypocalcemia. A presumptive diagnosis of dilated cardiomyopathy was considered by echocardiography and endomyocardial biopsies were consistent with cardiomyopathy. The coronary angiograms were normal and there was no apparent cause for dilated cardiomyopathy in these patients. The history of the patients and partial recovery of cardiac function after restoration of normocalcemia suggest that hypocalcemia was the cause of dilated cardiomyopathy.

Keywords:
Hypocalcemia, Hypoparathyroidism, Cardiomyopathy
1.
Boshour T, Basha HS, Cheng TO: Hypocalcemic cardiomyopathy. Chest 1980;78:663–665.
2.
Rimailho A, Bouchard P, Schaison G, Richard C, Auzepy P: Improvement of hypocalcemic cardiomyopathy by correction of serum calcium level. Am Heart J 1985;109:611–613.
3.
Kudah C, Tanaka S, Marusaki S, Takahashi N, Miyazaki Y, Yoshioka N, Hayashi M, Shimamoto K, Kikuchi K, Iimura O: Hypocalcemic cardiomyopathy in a patient with idiopathic hypoparathyroidism. Intern Med 1992;31:561–568.
4.
Huddle KR: Cardiac dysfunction in primary hypoparathyroidism: A report of 3 cases. South Afr Med J 1988;73:242–244.
5.
Huddle KR, Dubb A, Herman V: The cardiomyopathy of primary hypoparathyroidism: A case report. South Afr Med J 1982;61:804–805.
6.
Giles TD, Iteld BJ, Rives KL: The cardiomyopathy of hypoparathyroidism: Another reversible form of heart muscle disease. Chest 1981;79:225–229.
7.
Fisher NG, Armitage A, McGonigle RJ, Gilbert TJ: Hypocalcaemic cardiomyopathy: The relationship between myocardial damage, left ventricular function, calcium and ECG changes in a patient with idiopathic hypocalcaemia. Eur J Heart Fail 2001;3:373–376.
8.
Gulati S, Bajpai A, Juneja R, Kabra M, Bagga A, Kalra V: Hypocalcemic heart failure masquerading as dilated cardiomyopathy. Indian J Pediatr 2001;68:287–290.
9.
Abdullah M, Bigras JL, McCrindle BW, Mustafa A: Dilated cardiomyopathy as a first sign of nutritional vitamin D deficiency rickets in infancy. Can J Cardiol 1999;15:699–701.
10.
Uysal S, Kalayci AG, Baysal K: Cardiac functions in children with vitamin D deficiency rickets. Pediatr Cardiol 1999;20:283–286.
11.
Suzuki T, Ikeda U, Fujikawa H, Saito K, Shimada K: Hypocalcemic heart failure: A reversible form of heart muscle disease. Clin Cardiol 1998;21:375.
12.
Rallidis LS, Gregoropoulos PP, Papasteriadis EG: A case of severe hypocalcaemia mimicking myocardial infarction. Int J Cardiol 1997;61:89–91.
© 2003 S. Karger AG, Basel
2003
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