Objectives: To investigate the effects of Ramdan fasting on plasma levels of ACTH and cortisol in athletic students living in the Jordan Valley (JV) and compare them to those living at above sea level in Ramtha City (RC). Methods: Sample collection and measurements were done in November 1998 from non-fasting and in December 1998 from fasting people. Results: ACTH levels in non-fasting subjects in the JV were 36 ± 4 IU/ml compared to 43 ± 3 IU/ml for those in RC. Cortisol levels were 483 ± 76 (JV) and 539 ± 89 nmol/l (RC). Fasting led to an increase in ACTH (49 ± 6 (JV) and 58 ± 5 IU/ml (RC)) and cortisol levels (637 ± 101 (JV) and 805 ± 72 nmol/l (RC)). Conclusion: Fasting increases ACTH and cortisol levels in an altitude-independent fashion.

Bashir N, El-Migdadi F, Hasan Z, Al-Hader A-A, Wesermes I, Gharaibeh M: Effect of exercise at low altitude on hormones of the anterior pituitary and cortisol in athletes. Endocr Res 1996;22:289–298.
El-Migdadi F, Bashir N, Hasan Z, Al-Hader A-A, Gharaibeh M: Exercise at low altitude (Jordan Valley) causes changes in serum levels of ACTH, insulin, cortisol and lactate. Endocr Res 1996;22:763–767.
El-Migdadi F, Bashir N, Mohammad MJ, Brownie AC: Thyroid response to exercise at low altitude (Jordan Valley) is confined to changes in triiodothyronine (T3). Horm Metab Res 1997;29:196.
El-Migdadi F, Khatib SY, Bashir N: A comparative study of the effect of exercise on lactate dehydrogenase activity in athletes at below sea level environment (–350 meters) and that at above sea level altitude (620 meters). Submitted.
Galbo H: Hormonal and Metabolic Adaptation to Exercise. Stuttgart, Thieme, 1983.
Jones MT, Gillham B: Factors involved in the regulation of adrenocorticotropic hormone/beta-lipotropic hormone. Physiol Rev 1988;68:743–818.
Schatzberg AF, Nemeroff CB (eds): The Hypothalamic-Pituitary-Adrenal Axis. New York, Raven Press, 1988.
Burchfield SR: Stress: Physiological and Psychological Interactions. Washington, Hemisphere, 1985.
Newsholme EA, Leech AR: Integration of carbohydrate and lipid metabolism. Metabolism in exercise. Integration of metabolism during starvation, refeeding and injury; in Turner AJ, Higgins SJ, Wood EJ (eds): Biochemistry for the Medical Sciences: An Integrated Case Approach. New York,Wiley, 1983.
Bogdan A, Bouchareb B, Touitou Y: Ramadan fasting alters endocrine and neuroendocrine circadian patterns. Meal-time as a synchronizer in humans. Life Sci 2001;68:1607–1615.
Al-Hadramy MS, Zawawi TH, Abdelwahab SM: Altered cortisol levels in relation to Ramadan. Eur J Clin Nutr 1988;42:359–362.
Haouari M, Haouari Oukerro F, Nagati K: Circadian evolution of serum levels of glucose, insulin, cortisol and proteins in healthy, fasting volunteers. 2nd Int Congr on Ramadan and Health. Istanbul, 1997, p 31.
Garrel DR: Corticosteroid-binding globulin during inflammation and burn injury: Nutritional modulation and clinical implications. Horm Res 1996;45:245–251.
Rosner W: Plasma steroid-binding proteins. Endocrinol Metab Clin North Am 1991;20:697–720.
Seralini GE: Regulation factors of corticosteroid-binding globulin: Lesson from ontogenesis. Horm Res 1996;45:192–196.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.