PPARβ is expressed in the mouse epidermis during fetal development, and progressively disappears from the interfollicular epidermis after birth. Interestingly, its expression is strongly reactivated in the adult epidermis in conditions where keratinocyte proliferation is induced and during wound healing. Data obtained on PPARβ heterozygous mice reveal that PPARβ is implicated in the control of keratinocyte proliferation and is necessary for rapid healing of a skin wound.

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