In boys with constitutional delay of growth and puberty, adult height may be inconsistent with parental (target) height. We aimed at studying which period of growth was important to account for adult height being above or below target height. In this retrospective study, adult height measured after 20 years in 39 patients was compared with target height and height data obtained at about 6 and 12 years of age and at diagnosis of delayed puberty (mean 14.6 years). Twenty-eight patients were untreated while 11 received testosterone enanthate (50 or 100 mg/month for 6 months). The growth data from both groups were pooled since they were not different. On average, the adult height standard deviation score (–0.6 ± 0.8, mean ± SD) was similar to target height (–0.5 ± 0.6). There were, however, marked individual differences since adult height varied between 1.7 SD (11 cm) below target height and 1.4 SD (9.5 cm) above target height. Multiple regression analysis showed that the most significant determinant of the difference between adult height and target height was height catch up during puberty (p < 0.002). We conclude that the magnitude of height catch up during puberty is a significant determinant of adult height in boys with constitutional delay of growth and puberty. Thus, optimizing pubertal growth may be a relevant therapeutic aim for adult height in boys with short stature and delayed puberty.

1.
Wilkins L: Delay in the onset of adolescent growth and development; in Wilkins L (ed): The Diagnosis and Treatment of Endocrine Disorders in Childhood and Adolescence. Springfield, Thomas, 1965, pp 164–170.
2.
Prader A: Delayed adolescence. Clin Endocrinol Metab 1975;4:143–155.
3.
Rochiccioli P, Tock Mine YY, Enjaume C, Dutau G, Sablayrolles B: Le retard de maturation osseuse est un élément favorable du pronostic de la taille définitive. Arch Fr Pédiatr 1985;42:273–276.
4.
Zachmann M, Studer S, Prader A: Short-term testosterone treatment at bone age of 12 to 13 years does not reduce adult height in boys with constitutional delay of growth and adolescence. Helv Paediatr Acta 1987;42:21–28.
5.
Wilson DM, Kei J, Hintz RL, Rosenfeld RG: Effects of testosterone therapy for pubertal delay. Am J Dis Child 1988;142:96–99.
6.
Volta C, Ghizzoni L, Buono T, Ferrari F, Virdis R, Bernasconi S: Final height in a group of untreated children with constitutional growth delay. Helv Paediatr Acta 1988;43:171–176.
7.
Brämswig JH, Fasse M, Holthoff ML, von Lengerke HJ, von Petrykowski W, Schellong G: Adult height in boys and girls with untreated short stature and constitutional delay of growth and puberty: Accuracy of five different methods of height prediction. J Pediatr 1990;117:886–891.
8.
von Kalckreuth G, Haverkamp F, Kessler M, Rosskamp RH: Constitutional delay of growth and puberty: do they really reach their target height? Horm Res 1991;35:222–225.
9.
Sperlich M, Butenandt O, Schwarz HP: Final height and predicted height in boys with untreated constitutional growth delay. Eur J Pediatr 1995;154:627–632.
10.
Arrigo T, Cisternino M, De Luca F, Saggese G, Messina MF, Pasquino AM, De Scantis V: Final height outcome in both untreated and testosterone-treated boys with constitutional delay of growth and puberty. J Pediatr Endocrinol Metab 1996;9:511–517.
11.
Crowne EC, Shalet SM, Wallace WHB, Eminson DM, Price DA: Final height in boys with untreated constitutional delay in growth and puberty. Arch Dis Child 1990;65:1109–1112.
12.
Willig RP, Mahnke K, Stahnke N, Commentz JC, Sinnecker G, Winkler P: Height predictions and final height in boys with constitutional delay of growth and puberty (abstract). Horm Res 1990;33(suppl 3):34.
13.
Albanese A, Stanhope R: Predictive factors in the determination of final height in boys with constitutional delay of growth and puberty. J Pediatr 1995;126:545–550.
14.
Schroor EJ, van Weissenbruch MM, Knibbe P, Delemarre-van de Waal H: The effect of prolonged administration of an anabolic steroid (oxandrolone) on growth in boys with constitutionally delayed growth and puberty. Eur J Pediatr 1995;154:953–957.
15.
LaFranchi S, Hanna CE, Mandel SH: Constitutional delay of growth: Expected versus final adult height. Pediatrics 1991;87:82–87.
16.
Tanner JM, Whitehouse RH, Takaishi M: Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. Arch Dis Child 1966;41:613–635.
17.
Tanner JM, Goldstein H, Whitehouse RH: Standards for children’s height at ages 2–9 years allowing for height of parents. Arch Dis Child 1970;45:755.
18.
Tanner JM, Whitehouse RH, Cameron N, Marshall WA, Healy MJR, Goldstein H: Assessment of Skeletal Maturity and Prediction of Adult Height (TW2 Method), ed 2. London, Academic Press, 1983.
19.
Ryan R, Heaney RP: Relation between measured and recalled body height. N Engl J Med 1988;319:795–796.
20.
Vercauteren M, Susanne C: The secular trend of height and menarche in Belgium: Are there any signs of a future stop? Eur J Pediatr 1995;144:306–309.
21.
Maes M, Vandeweghe M, Du Caju M, Ernould Ch, Bourguignon JP, Massa G: A valuable improvement of adult height prediction methods in short normal children. Horm Res 1997;48:184–190.
22.
Burns EC, Tanner JM, Preece MA, Cameron N: Final height and pubertal development in 55 children with idiopathic growth hormone deficiency, treated for between 2 and 15 years with human growth hormone. Eur J Pediatr 1981;137:155–164.
23.
Bourguignon JP, Vandeweghe M, Vanderschueren-Lodeweyckx M, Malvaux P, Wolter R, Du Caju M, Ernould C: Pubertal growth and final height in hypopituitary boys: A minor role of bone age at onset of puberty. J Clin Endocrinol Metab 1986;63:376–382.
24.
Massa G, Vanderschueren-Lodeweyckx M, Malvaux P: Linear growth in patients with Turner syndrome: influence of spontaneous puberty and parental height. Eur J Pediatr 1990;149:246–250.
25.
Rochiccioli R, David M, Malpuech G, Colle M, Limal JM, Battin J, et al: Study of final height in Turner’s syndrome: Ethnic and genetic influences. Acta Paediatr 1994;83:305–308.
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