This paper reports 3 cases of congenital GH deficiency with male pseudohermaphroditism. All 3 showed a normal male karyotype, hypospadias of different degrees, and, for 2 of them, micropenis. No müllerian structure was individualized since pelvic ultrasound and genitography were normal. Patient 1 was born with multiple anomalies and patient 3 showed partial agenesia of the corpus callosum. Only 1 patient showed complete anterior pituitary deficiency. Gonadotropin defects were not investigated. We postulate that GH might play a role in early testosterone stimulation, and thus in male sexual differentiation.

1.
Siiteri PK, Wilson JD: Testosterone formation and metabolism during male sexual differentiation in the human embryo. J Clin Endocrinol Metab 1974;38:113–117.
2.
Saenger P: Abnormal sex differentiation. J Pediatr 1984;104:1–14.
3.
Sadeghi-Nejad A, Senior B: A familial syndrome of isolated ‘aplasia’ of the anterior pituitary. Diagnostic studies and treatment in the neonatal period. J Pediatr 1974;84:79–84.
4.
Cacciari E, Cicognani A, Pirazzoli P, Tassoni F, Bernardi S, Salardi F, Zappulla L, Mazzanti L: Congenital hypopituitarism associated with neonatal hypoglycemia and microphallus: Effect of GH therapy. Helv Paediatr Acta 1976;31:481–485.
5.
Burgner DP, Kinmond S, Wallace AM, Young DG, Forest MG, Donaldson MDC: Male pseudohermaphroditism secondary to panhypopituitarism. Arch Dis Child 1996;75:153–155.
6.
Albers N, Ulrichs C, Glüer S, Hiort O, Sinnecker GHG, Mildenberger H, Brodehl J: Etiologic classification of severe hypospadias: Implications for prognosis and management. J Pediatr 1997;131:386–392.
7.
Laron Z, Sanel R: Penis and testicular size in patients with growth hormone insufficiency. Acta Endocrinol 1970;63:625–633.
8.
Laron Z, Klinger B: Effect of insulin-like growth factor-1 treatment on serum androgens and testicular and penile size in males with Laron syndrome (primary growth hormone resistance). Eur J Endocrinol 1998;138:176–180.
9.
Nguyen AP, Chandorkar A, Gupta C: The role of growth hormone in fetal mouse reproductive tract differentiation. Endocrinology 1996;137:3659–3666.
10.
Schonfeld WA, Beebe GW: Normal growth and variation in the male genitalia from birth to maturity. J Urol 1942;48:759–777.
11.
Feldman KW, Smith DW: Fetal phallic growth and penile standards for mewborn male infants. J Pediatr 1975;86:395–398.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.