Abstract
Boys are heavier than girls at term birth. Children with a 46,XY karyotype and androgen insensitivity syndrome (clinically complete form and/or proven mutations in the androgen receptor gene) were found to have a birth weight comparable to that of girls. These findings support the hypothesis that the difference in birth weight between boys and girls is generated by androgen action.
References
1.
Ounsted C, Ounsted M: Effect of Y chromosome on fetal growth rate. Lancet 1970;ii:857–858.
2.
French FS, Lubahn DB, Brown TR, et al: The molecular basis of androgen insensitivity. Recent Prog Horm Res 1990;46:1–38.
1998
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