In order to evaluate the galactopoietic response to rhGH in mothers of normal babies with idiopathic lactation insufficiency arising in the early postpartum period, we performed a preliminary, randomised, single blind trial of 3 different doses of hGH: either 0.05, 0.1, or 0.2 IU/kg/day to a maximum of 16 IU/day, for 7 days. Total 24-hour milk production was determined in each mother 1 day prior to initiating therapy and on the last day of therapy. Milk production rose by 36.0 ± 12.6% in the group receiving 0.2 IU/kg/day (n = 6) but by only 4.7 ± 9.7%, (p < 0.04) in the combined lower dose group (n = 10). In conclusion, these data suggest that moderate dose hGH therapy in mothers with lactation insufficiency can improve galactopoiesis.

Gunn TR: Breast feeding preterm infants. NZ Med J 1991;104:187–188.
Hennart P, Delogne-Desnoeck J, Vis H, Robyn C: Serum levels of prolactin and milk production in women during a lactation period of thirty months. Clin Endocrinol 1981;14:349–353.
Breier BH, Gluckman PD, McCutcheon SN, Davis SR: Physiological responses to somatotropin in the ruminant. J Dairy Sci 1991;74:20–34.
Kauppila A, Kivinen S, Ylikorkala O: Metoclopramide increases prolactin release and milk secretion in puerperium without stimulating the secretion of thyrotropin and thyroid hormones. J Clin Endocrinol Metab 1981;52:436–438.
Milsom SR, Breier BH, Gallaher BW, Cox VA, Gunn AJ, Gluckman PD: Growth hormone stimulates galactopoiesis in healthy lactating women. Acta Endocrinol Copenh 1992;127:337–343.
Gunn AJ, Gunn TR, Rabone DL, Breier BH, Blum WF, Gluckman PD:. Growth hormone increases breast milk volumes in mothers of preterm infants. Pediatrics 1996;98:279–282.
Breier BH, Milsom SR, Blum WF, Schwander J, Gallaher BW, Gluckman PD: Insulin-like growth factors and their binding proteins in plasma and milk after growth hormone-stimulated galactopoiesis in normally lactating women. Acta Endocrinol Copenh 1993;129:427–435.
Segura-Millan S, Dewey KG, Perez-Escamilla R: Factors associated with perceived insufficient milk in a low-income urban population in Mexico. J Nutr 1994;124:202–212.
Forman MR, Lewando Hundt G, Graubard BI, Chang D, Sarov B, Naggan L, Berendes HW: Factors influencing milk insufficiency and its long-term health effects: The Bedouin Infant Feeding Study. Int J Epidemiol 1992;21:53–58.
Essex C, Smale P, Geddis D: Breastfeeding rates in New Zealand in the first 6 months and the reasons for stopping. NZ Med J 1995;108:355–357.
Yoneda N, Irahara M, Saito S, Uemura H, Aono T: Usefulness of recombinant human prolactin for treatment of poor puerperal lactation in a rat model. Eur J Endocrinol 1995;133:613–617.
Livingstone VH, Gout PW, Crickmer SD, Fox K, Prior JC: Serum lactogens possessed normal bioactivity in patients with lactation insufficiency. Clin Endocrinol 1994;41:193–198.
Daly SE, Owens RA, Hartmann PE: The short-term synthesis and infant-regulated removal of milk in lactating women. Exp Physiol 1993;78:209–220.
De Coopman J: Breastfeeding after pituitary resection: Support for a theory of autocrine control of milk supply? J Hum Lact 1993;9:35–40.
Wilde CJ, Addey CV, Boddy LM, Peaker M: Autocrine regulation of milk secretion by a protein in milk. Biochem J 1995;305:51–58.
Li M, Liu X, Robinson G, Bar-Peled U, Wagner KU, Young WS, Hennighausen L, Furth PA: Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution. Proc Natl Acad Sci USA 1997;94:3425–3430.
Heermeier K, Benedict M, Li M, Furth P, Nunez G, Hennighausen L: Bax and Bcl-xs are induced at the onset of apoptosis in involuting mammary epithelial cells. Mech Dev 1996;56:197–207.
Akers RM: Lactogenic hormones: Binding sites, mammary growth, secretory cell differentiation and milk biosynthesis in ruminants. J Dairy Sci 1985;68:501–519.
Davis SR, Gluckman PD, Hart IC, Henderson HV: Effects of injecting growth hormone or thyroxine on milk production and blood plasma concentrations of insulin-like growth factors I and II in dairy cows. J Endocrinol 1987;114:17–24.
Prosser CG, Davis SR, Farr VC, Moore LG, Gluckman PD: Effects of close-arterial (external pudic) infusion of insulin-like growth factor-II on milk yield and mammary blood flow in lactating goats. J Endocrinol 1994;142:93–99.
Neuenschwander S, Schwartz A, Wood TL, Roberts CT Jr, Henninghausen L, LeRoith D: Involution of the lactating mammary gland is inhibited by the IGF system in a transgenic mouse model. J Clin Invest 1996;97:2225–2232.
Knight CH, Hillerton JE, Kerr MA, Teverson RM, Turvey A, Wilde CJ: Separate and additive stimulation of bovine milk yield by the local and systemic galactopoietic stimuli of frequent milking and growth hormone. J Dairy Res 1992;59:243–252.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.