Epinephrine diminished in vitro uptake of 3H-estradiol by the uterus of spayed rats treated with estradiol (2 µg) for 3 days. This effect was observed at 15 min in the cytosol and at 30 min in the nuclear fraction. Epinephrine did not show any action when incubated with uterine homogenates suggesting that in order to act this catecholamine requires an intact tissue or a complete cellular structure. The in vivo uptake of 3H-estradiol and determination of the number Binding sites of binding sites were performed in the uterus of rats treated with different amounts of estradiol and estradiol plus epinephrine for 3 days. Epinephrine alone had no effect, but epinephrine plus 0.4 µg of estradiol decreased uptake of 3H-estradiol and the number of binding sites, although the dose of 2 µg of estradiol increased these two parameters. The increase in estradiol uptake and the number of binding sites produced by epinephrine when the large dose of estradiol was utilized could be explained by the effects obtained by injecting estradiol alone; this shows that larger amounts of estradiol decreased uptake and number of binding sites. These results suggest that epinephrine decreases both in vitro and in vivo the influx of estradiol into the rat’s uterus.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.