To determine the final height of patients with precocious pubery treated with medroxyprogesterone acetate (MPA; 150 mg every week) for a period > 1 year (mean ± SD = 3.24 ± 1.85 years), data from a group of 26 girls were analyzed. The attained final height was 155.6 ± 8.06 cm ( 1.1 SD of the normal population). In a group of 8 untreated girls with precocious puberty, adult height was 149.2 ± 5.07 (-2.16 SD, p < 0.02). In 9 patients in whom treatment was stopped at a bone age ≤ 12 years, final height was 159.2 ± 10.05 cm, while in 16 girls who had a bone age > 12 years at the end of treatment, the final height was 153.03 ± 6.28 cm. Our data demonstrate the effectiveness of MPA treatment on ultimate height. The better height observed in those patients who stopped treatment with a bone age < 12 years suggests the advantage of discontinuing therapy before reaching a more advanced degree of skeletal maturation.

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