Previous work in our laboratory has defined two estrogen binders in male rat liver cytosol, one a putative estrogen receptor found in both sexes, and the other a species unique to the male. We tested other tissues of male rats by gel filtration chromatography and estrogen binding studies to detect whether similar protein species were present. Several of the tissues assayed contained a high affinity receptor-like molecule: pancreas > liver > kidney > lung > testes > scrotal skin. This species could not be detected in spleen, jejunum, and epididymis. The same tissues were also assayed to detect the male-specific estrogen binding protein. This protein was undetectable in any other tissues examined and appears to be specific for liver tissue. Because of this tissue specificity, we have postulated a role for it as a mechanism for binding and possibly eliminating excess estrogen in the male.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.