After intravenous injection of 125I-ACTH 1-24 into rats, the highest concentration of l25I was found in kidneys, adrenal, and liver. Addition of 5- and 30-fold excess unlabelled ACTH reduced the uptake of 125I by 50 and 68%, respectively, indicating that the adrenal uptake was specific. Pretreatment with dexamethasone decreased the adrenal uptake of 125I and caused adrenal atrophy. Chronic ACTH treatment increased the size of the adrenals, but did not affect the adrenal uptake of 125I. These experiments demonstrate selective uptake of 125I by the adrenals after administration of 125I-ACTH1-24.

Keywords:
125I-ACTHU24, Adrenal uptake, ACTH distribution, Dexamethasone
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© 1981 S. Karger AG, Basel
1981
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