The effect of hypo- and hyperglycemia on the renin-aldosterone system was studied in 10 endocrinologically normal children. Insulin-induced hypoglycemia caused an elevation of plasma renin activity (PRA) up to 371 ± 23% (mean ± SEM) over the basal level (p < 0.001) and of the plasma aldosterone level up to 243 ± 7% (mean ± SEM) over the basal values (p < 0.001). Hyperglycemia caused an elevation of PRA up to 135 ± 40% (mean ± SEM) over the basal values (p > 0.05) and a reduction in the plasma aldosterone level to 53 ± 12% (mean ± SEM, p < 0.01). It is suggested that the widely used diagnostic procedures, the insulin tolerance and oral glucose tolerance tests, be also applied for the investigation of the renin-aldosterone system.

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