A pronounced lipolytic activity was found in homogenate of rat adrenal gland. The pH optimum of adrenal lipase was wide and the highest lipolytic activity was found at pH 8.5. An inhibition of lipolytic activity in the presence of 1 M NaCl, protamine sulphate, diisopropylfluorophosphate at pH 8,5 and after the addition on NaF at pH 7.2 was noted. Heparine activated the lipase activity at pH 8.5. These result suggested that both lipoprotein like lipase and neutral ‘tissue’ lipase are present in rat adrenal gland. An activation of adrenal lipase activity with ACTH and 3’5’ cyclic adenosine monophosphate was demonstrated. The other pituitary hormones and adrenaline did not increased the adrenal lipase activity.

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