... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Amyotrophic lateral sclerosis Familial Genetic models Penetrance Population genetics Segregation analysis Sporadic...

... for gestational age, a quantitative proxy for preterm birth. Methods: Because either mother or infant can be considered the proband from a preterm delivery and there is evidence to suggest that genetic factors in either one or both may influence the trait, we performed segregation analysis for gestational age...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Path analysis Regressive model Segregation analysis TAU path model Heritability Original Paper Hum Hcrccl 1944;44...

...Lue Ping Zhao; John S. Grove To eliminate the need for distributional assumptions and to reduce the computational burden associated with the method of maximum likelihood, several researchers have proposed using estimating equations techniques for segregation analysis. One concern...

...), by failing to reject the hypothesis of Mendelian transmission and by rejecting the hypothesis of nontransmission of a major gene ( χ 2 3 = 0.07 – 0.0 = 0.07, p > 0.99; χ 2 2 = 198.28 – 0.0 = 198.28, p < 0.0001). Mitsuda reaction Leprosy Segregation analysis Genetic epidemiology © 1996 S...

...Denis C. Shields; Angela J. Marlow; Richard S. Houlston; Diana M. Eccles; Newton E. Morton Segregation analysis provides a genetic model of disease based upon morbid risks in age-specific classes, from which the model derives genotype-specific morbid risks. In the absence of disease-specific...

...Maurizio Clementi; Romano Tenconi; Andrew Collins; Elisa Calzolari; Mario Milan The mode of inheritance of cleft lip with or without cleft palate (CL/P) has been extensively investigated, but the results are controversial. We report results of complex segregation analysis performed in the families...

...C.L. Carter; W.B. Kannel A major risk factor for coronary heart disease in both men and women is elevated systolic blood pressure (SBP). We performed segregation analysis on age, sex-adjusted, and transformed systolic blood pressure data on 1,141 families from the Framingham cohort-offspring study...

... visiting an allergy clinic. Although the mean IgE levels were elevated (mean 637 U/ml), the prevalence of atopic disease in this population was surprisingly low. When the data were analyzed using complex segregation analysis, no major locus could be detected. Moreover, the polygenic heritability...

... to in the content or advertisements. Family data Genetic analysis Linkage analysis Logistic regression Regressive models Segregation analysis Hum H ercd 1992;42:28-41 George Ebow Bonney Department of Biostatistics, Fox Chase Cancer Center, Philadelphia, Pa., USA Compound Regressive Models for Family...

...Y.F. Friedlander; J.D. Kark Plasma lipid and lipoprotein concentrations from 3,074 nuclear families in the multiethnic Jerusalem Lipid Research Clinic study population were analyzed for possible involvement of major genes in determination of high levels of these traits. Complex segregation analysis...

...Guido Barbujani; Manuel Rolo; Italo Barrai; Juan Pinto-Cisternas Segregation analysis of 99 sibships in 2 samples from Venezuela and Japan indicates that a torus palatinus is inherited in simple dominant fashion. The gene shows variable expressivity and penetrance close to 85%, without significant...

...Fu Weimin; Guido Barbujani In the Henan province, China, the segregation ratio of Duchenne muscular dystrophy, estimated through classical segregation analysis on 103 sibships, is p = 0.462, and the maximum likelihood proportion of sporadic cases is x = 0.264. These figures are in agreement...

... and to decrease the estimated contribution of cultural inheritance. Segregation analysis of the residual phenotypes in 44 nuclear families was carried out to determine whether another major gene, other than the Pi locus, may be influencing pulmonary function in this population. Statistical evidence was found...

... uridyltransferase (GALT) polymorphism. Electrophoresis and quantitative assay of GALT activity were not always sufficient for an accurate identification of the different GALT genotypes; segregation analysis provided better criteria for classification. A parent-child correlation coefficient for GALT activity equal...

... support was found for a major gene hypothesis by complex segregation analysis under the mixed model. However, all the evidence came just from one family in which one of the 3 children’s zinc value was over 3 standard deviations above the mean. When that family was excluded, there was no more evidence...

...Geoffrey C. Ashton Segregation analysis of ocular spherical refraction data using a unified model resulted in rejection of a Mendelian hypothesis of genetic transmission in nuclear families of both Japanese and European ancestries. Similar analyses of families which included at least 1 myope gave...

...C.L. Carter; C.S. Chung Family data were collected on a multi-ethnic cohort of hospitalized schizophrenics in Hawaii in 1942, Results showed that prevalence rates for Orientals were significantly higher (p < 0.001) than rates for Caucasians, Polynesians and others. Complex segregation analysis...

..., instructions or products referred to in the content or advertisements. Transmission probability Pedigree data Segregation analysis 29 8 2008 Hum. Hered. 31: 93-99 (1981) A General Transmission Probability Model for Pedigree Data1 F. M. Demenais and R. C. Elston Groupe de Recherches de...

...S.S. Agarwal; U.C. Lahori; S.K. Mehta; D.G. Smith; P.C. Bajpai Detailed pedigree charts were prepared from 120 index patients suffering from Indian childhood cirrhosis (ICC). Of the 120 families, 84 were informative for segregation analysis. Since families were ascertained through patients who came...