... of single-split solutions. Methods: To assess whether MS can achieve a comparable power to a full pedigree analysis, we compared the power of linkage on a very large pedigree in both simulated and real-case scenarios, using variance components linkage analysis of a dense SNP array. Results: Our results...

...Kuang-Fu Cheng; Jen-Yu Lee There are several well-known single SNP tests presented in the literature for detecting gene-disease association signals. Having in place an efficient and robust testing process across all genetic models would allow a more comprehensive approach to analysis. Although some...

... model. Through a Monte Carlo simulation study, we show that the proposed association test is generally more powerful than the χ 2 test, and more robust than those trend-based tests. The proposed methodologies are also illustrated by some real SNP datasets. 23 08 2011 25 10 2011 30 12...

... infection. Methods: 764 subjects previously immunized with measles-mumps-rubella vaccine were genotyped for 66 candidate SNPs in the CD46, SLAM and CD209 genes as part of a larger study. Results: A previously detected association of the CD46 SNP rs2724384 with measles-specific antibodies was successfully...

... studies to detect SNPs which have significant control on human blood pressure. The traditional false discovery rate is used for multiple comparisons. Results: We analyze the data from the Framingham Heart Study to detect such SNPs by appropriately considering gender-gene interaction. We detect 8 SNPs...

...Annette M. Molinaro; Nicholas Carriero; Robert Bjornson; Patricia Hartge; Nathaniel Rothman; Nilanjan Chatterjee Background: Genetic association studies, thus far, have focused on the analysis of individual main effects of SNP markers. Nonetheless, there is a clear need for modeling epistasis...

.... They compared their method with several others using simulated data, establishing that their PLS test performed best. Unfortunately, Wang et al. did not include in their evaluations several powerful tests just recently discovered for analyzing multiple SNPs in a candidate gene or region. Methods: In this paper...

... between cases and controls, our proposed tests are sensitive to both. Original Paper Hum Hered 2010;69:1 13 DOI: 10.1159/000243149 Received: February 9, 2009 Accepted after revision: April 27, 2009 Published online: October 2, 2009 A Unified Framework for Detecting Genetic Association with Multiple SNPs...

... ≧+1) were studied. The LRP5 gene was sequenced for single nucleotide polymorphisms (SNPs) and 4 SNPs were tagged from 8 genotyped SNPs for this study. Results: Single locus allele association tests revealed significant associations of rs682429 and rs686921 with BMD variation (p < 0.05). Omnibus...

... study is to systematically study the relation of ALOX15 polymorphisms in BMD variation in southern Chinese women. Methods: Ten tag single nucleotide polymorphisms (SNP) were genotyped in 942 subjects with either low BMD (defined by a BMD Z score ≤–1.28 at either the hip or spine) or high BMD (Z score...

... polymorphisms (SNPs) and lipid levels in an Amish population to assess sex and age differences. Methods: Eight SCARB1 SNPs, identified from public databases, were genotyped in 919 subjects. Results: Rs5888 and rs3782287 were in high linkage disequilibrium (LD), with r 2 > 0.8. None of the SNPs were...

...Valentina Moskvina; Karl Michael Schmidt Objectives: In view of the linkage disequilibrium structure of the genome, the selection of maximally informative SNP markers is a fundamental issue in the design of association studies. Currently used selection methods rely on pairwise marker correlation...

..., or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. SNP...

... to in the content or advertisements. Iran Y-chromosome SNP Original Paper Hum Hered 2006;61:132 143 DOI: 10.1159/000093774 Received: December 12, 2005 Accepted: March 23, 2006 Published online: June 12, 2006 Iran: Tricontinental Nexus for Y-Chromosome Driven Migration M. Regueiroa A.M. Cadenasa T...

...Joanna Polanska; Marek Kimmel We propose a simple model of evolution at a pair of SNP loci, under mutation, genetic drift and recombination. The developed model allows to consider evolution of SNPs under different demographic scenarios. We applied it to SNP data containing polymorphisms spanning 19...

...-like growth factor 2 antisense (IGF2AS), and the insulin gene, all important candidate genes for various diseases, including cancer, obesity, diabetes, and coronary disease. While single nucleotide polymorphisms (SNPs) have been identified for this region and used in association studies, ethnic...

... marker-marker linkage disequilibrium on SNPs typed in and around all genes on a chromosome. The test statistic used is the classic likelihood ratio test applied to haplotypes in case/control populations. Haplotype frequencies are computed through specification of genetic model parameters. Power...

... as the size of the pedigree increases. For larger pedigrees, the probabilities of confirming or rejecting a deletion are higher than 0.9 for SNPs having a minor allele frequency greater than 0.4. The probabilities are higher using multiallelic markers such as microsatellites, reaching levels as high as 0.9...

.... The sequence alignment of the COL3A1 insertion from several African individuals revealed a bi-allelic single nucleotide polymorphism (SNP) at the downstream terminus of the element’s poly-A tract. Once discovered, a selective PCR procedure was designed to determine the frequency of both alleles in 19 worldwide...

...E. Cousin; E. Genin; S. Mace; S. Ricard; C. Chansac; M. del Zompo; J.F. Deleuze Objective: When numerous single nucleotide polymorphisms (SNPs) have been identified in a candidate gene, a relevant and still unanswered question is to determine how many and which of these SNPs should be optimally...