.... Conditional maximum likelihood method Inbreeding coefficient Recessive disease Mutations Pathogenic allele frequency Congenital adrenal hyperplasia Original Paper Hum Hered 2015;80:69 78 DOI: 10.1159/000438862 Received: April 3, 2015 Accepted after revision: July 20, 2015 Published online: November 6...

... to illustrate the potential of cryptic population substructure (the Wahlund effect) to contribute to recessive disease incidence in populations with complex social structure. Method: Population parameter estimates were drawn from a recent study of the British Pakistani population along with allele frequency...