... investigated for 20 years, but the development of statistical methods for detecting parent-of-origin effects on the X chromosome is relatively new. In the literature, a class of Q-XPAT-type tests are the only tests for the parent-of-origin effects for quantitative traits on the X chromosome. In this paper, we...

... with quantitative traits called family-based quantitative Bayesian LASSO (famQBL). FamQBL can analyze any type of pedigree and is based on a mixed model framework. We regularize the haplotype effects using Bayesian LASSO and estimate the posterior distributions using Markov chain Monte Carlo methods. Results: We...

... Mother and Child Cohort (MoBa) study. Conclusion: We find a significant KIR - HLA-C interaction effect on birth weight. More generally, the QMFG test can detect genetic associations that may be missed by standard genome-wide association studies for quantitative traits. [email protected]...

...Charalampos Papachristou; Shili Lin Aims: We introduce a family-based confidence set inference (CSI) method that can be used in preliminary genome-wide association studies to obtain confidence sets of SNPs that contribute a specific percentage to the additive genetic variance of quantitative traits...

... in the updated FBAT version v2.0.4) have applied collapsing methods analogously in family-based designs. For further research in this area, this study aims to introduce three new beta-determined weight tests for detecting rare variants for quantitative traits in nuclear families. In addition to evaluating...

... disequilibrium (LD), or association analysis, in case-control data, trio data, and/or multiplex family data, with options for joint linkage and trait-marker LD or conditional LD given linkage; dichotomous trait, quantitative trait and quantitative trait threshold models; and certain types of gene-gene...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Linkage analysis Biological markers Quantitative traits 4 02 1994 9 11 1994 3 9 2008 Jurg Ott Columbia University, Department of Psychiatry, New York...

...C.M. Kammerer; J.W. MacCluer Two methods of quantitative linkage analysis were evaluated as screening tests for the presence of major genes that influence the expression of a quantitative trait. Our analyses of computer-simulated pedigree data indicate that both methods can be very informative...

... not detect major genes in certain cases. The intrafamily correlations of Matthysse et al. are shown to yield values difficult to reconcile with established patterns of inheritance for certain traits. 2 9 2008 Major gene Major gene index Intrafamily correlations Quantitative traits Gene...

... trait within each genotype at the trait locus will be equal. Thus, the use of ANOVA may lead to misleading association inferences. In this article, we perform a simulation-based study to assess the rate of false positives and the power of ANOVA under various probability distributions of the quantitative...

...Christoph Lange; Helen Lyon; Dawn DeMeo; Benjamin Raby; Edwin K. Silverman; Scott T. Weiss We introduce a new powerful nonparametric testing strategy for family-based association studies in which multiple quantitative traits are recorded and the phenotype with the strongest genetic component...

...David B. Allison; Moonseong Heo; Nicholas J. Schork; Su-Ling Wong; Robert C. Elston It is well known that obtaining adequate statistical power to detect linkage to or association with genes for complex quantitative traits can be very difficult. In response, investigators have developed a number...