... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Extreme sampling Next-generation sequencing Pedigree samples Quantitative trait loci Rare variants National...

... between the traits. The inclusion of multiple quantitative trait loci in linkage analysis allows the inference of epistasis between loci. A user-friendly graphical user interface facilitates the usage of jPAP. National Institutes of Health (NIH) 10.13039/100000002 Hum Hered 2011;72:258 263...

... Quantitative trait loci influencing BMI in a large cohort collected in the PROCARDIS coronary heart disease study consisting of 1,812 informative families. Methods: Multipoint linkage analysis for BMI was conducted using both a variance component approach and a model-free regression method, and the resulting...

... in the pathogenesis of cardiovascular diseases (CVD). However, findings on the relations between ACEvariants and CVD have not been consistent. The purpose of this study was to map quantitative trait loci (QTL) for serum ACE activity, a heritable endophenotype of cardiovascular diseases (estimated heritability = 0.58...

... Genetic linkage Longitudinal data Random effect mixed model Quantitative trait loci Abstract We propose an extension to longitudinal data of the Hase- man and Elston regression method for linkage analysis. The proposed model is a mixed model having several random effects. As response variable, we...

... of the island’s original founder population. Triglycerides, cholesterol, and blood pressures all had heritabilities above 0.2. Conclusions: The Norfolk Island population is a potentially useful genetic isolate for gene mapping studies aimed at identifying CVD risk factor quantitative trait loci (QTL). 22 07...

... cases. 15 10 2003 16 02 2004 15 6 2004 Model free linkage analysis Haseman and Elston Quantitative trait loci Power Original Paper Hum Hered 2004;57:109 116 DOI: 10.1159/000077548 Received: October 15, 2003 Accepted after revision: February 16, 2004 A Modified Revisited...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Genome scan Quantitative trait loci Generalized least squares estimation Generalized estimating equations Permutation...

...Daniel J. Schaid; Jane M. Olson; W. James Gauderman; Robert C. Elston Regression methods offer a common framework to analyze linkage for quantitative trait loci as well as linkage for affection status using affected sib-pairs. Although numerous papers on regression methods for linkage have been...

...José R. Fernàndez; Carol Etzel; T. Mark Beasley; Sanjay Shete; Christopher I. Amos; David B. Allison Objectives: In sib pair studies, quantitative trait loci (QTL) identification may be adversely affected by non-normality in the phenotypic distribution, particularly when subjects falling...

... analysis Model-free multipoint linkage analysis Variance components analysis Transmission disequilibrium test Quantitative trait loci Traditionally, model-based linkage analysis, commonly known as logarithm of odds (lod) score analysis, was performed on multigenerational (extended) families...

..., London, bWellcome Trust Centre for Human Genetics, Oxford, UK, and cInstitute for Behavioral Genetics, University of Colorado, Boulder, Colo., USA Key Words Quantitative trait loci W Selection W Sibs W Linkage W Variance components W Methodology genotyping, the proposed method is considerably more...

... one has. In this paper, we show by simulation that this is not true under all circumstances. In particular, we show that under oligogenic models, where some biallelic quantitative trait loci (QTLs) have markedly asymmetric allele frequencies and large mean displacement among genotypes, and others have...