... was performed. The frequency of Hb S was 4.6% and β thalassemia 2.3%. In 35 of 2,113 prospective families, both partners were found to be carriers. During the 4-year follow-up period, prenatal diagnosis was sought in 10 pregnancies of these at-risk families. This study indicated that premarital screening...

... abnormalities in both cultured skin fibroblasts and cultured amniotic fluid fibroblasts. It was shown that control of culturing conditions made it possible to distinguish normal cell lines from certain cell lines carrying known genetic diseases. 28 8 2008 Fibroblasts Prenatal diagnosis...

...D.J.H. Brock Measurement of β-lipoprotein concentration in amniotic fluid is introduced as a new parameter for the early prenatal diagnosis of spina bifida. It was successful in 15 cases of spina bifida, but failed in 5 cases of open spina bifida and 2 cases of closed spina bifida. All assays were...