...Alexander Engelhardt; Anna Rieger; Achim Tresch; Ulrich Mansmann Objective: We analyze data sets consisting of pedigrees with age at onset of colorectal cancer (CRC) as phenotype. The occurrence of familial clusters of CRC suggests the existence of a latent, inheritable risk factor. We aimed...

...Jason P. Sinnwell; Terry M. Therneau; Daniel J. Schaid Background: The kinship2 package is restructured from the previous kinship package. Existing features are now enhanced and new features added for handling pedigree objects. Methods: Pedigree plotting features have been updated to display...

.... Genetics Pedigrees Relative risk Secularity Hum. Hered. 36: 227-232(1986) © 1986S. Kargcr AG. Basel 0001-5652/86/0364-0227 $ 2.75/0 Correcting for Variable Age of Onset in the Estimation of Familial Relative Risk when There Is a Secular Trend in Incidence of Disease R. W.C. Haile3, V.K. Cortessis H.3...

...Ranajit Chakraborty In elucidating the etiology of complex diseases through various epidemiologic and genetic analyses, it is necessary to define the expected risks for each member of a pedigree collected through an affected individual. It is shown that several factors are to be considered without...