... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Linkage analysis Data repositories Microsatellites SNPs Information content PPL National Institutes of Health (NIH) 10.13039/100000002 Original Paper Hum...

...M. Govil; V.J. Vieland Objective: The PPL, a class of statistics for complex trait genetic mapping in humans, utilizes Bayesian sequential updating to accumulate evidence for or against linkage across potentially heterogeneous data (sub)sets. Here, we systematically explore the relative efficacy...

... revisited this data set using a Bayesian linkage analysis technique, namely the posterior probability of linkage (PPL). Methods: The PPL has been developed as an alternative to traditional linkage analysis. It differs from both LOD scores and ‘non-parametric’ methods in that it directly measures...

..., University of Iowa, Iowa City, Iowa, USA Key Words Statistical evidence Measurement LODs p values PPL Abstract In human genetics, we measure the strength of statistical evidence using a variety of maximized likelihood ratios, LODs, and empirical p values. I argue here that these statis- tics have...

...Mark W. Logue; Veronica J. Vieland The posterior probability of linkage (PPL) is a Bayesian statistic which directly measures the probability of linkage between a trait locus and a marker (in the 2-point case) or a genomic region (in the multipoint case). It has several benefits, including ease...