...Tanja Stocks; Lars Ängquist; Jörg Hager; Celine Charon; Claus Holst; J. Alfredo Martinez; Wim H.M. Saris; Arne Astrup; Thorkild I.A. Sørensen; Lesli H. Larsen Background: TFAP2B rs987237 is associated with obesity and has shown interaction with the dietary fat-to-carbohydrate ratio, which has...

...John A. Dawson; Emily J. Dhurandhar; Ana I. Vazquez; Bo Peng; David B. Allison Background/Aims: To quantify the extent to which the increase in obesity observed across recent generations of the American population is associated with the individual or combined effects of assortative mating (AM...

...Shafqat Ahmad; Tibor V. Varga; Paul W. Franks Background/Aims: Obesity is a pervasive and highly prevalent disease that poses substantial health risks to those it affects. The rapid emergence of obesity as a global epidemic and the patterns and distributions of the condition within and between...

... to individual variation in obesity and body composition parameters, particularly among diverse admixed groups known to differ in obesity prevalence within the United States. Although progress has been made through the use of genetic admixture approaches, further investigations are needed in order to explore...

...Ellen W. Demerath; Audrey C. Choh; William Johnson; Joanne E. Curran; Miryoung Lee; Claire Bellis; Thomas D. Dyer; Stefan A. Czerwinski; John Blangero; Bradford Towne Objective: To test the hypothesis that the statistical effect of obesity-related genetic variants on adulthood adiposity traits...

...: Obesity is a major contributor to the global burden of chronic disease and disability, though current knowledge of causal biologic underpinnings is lacking. Through the regulation of energy homeostasis and interactions with adiposity and gut signals, the brain is thought to play a significant role...

...Kathryn A. Kaiser; Gary L. Gadbury Background/Aims: The rising prevalence of human obesity worldwide has focused research on a variety of interventions that result in highly varied degrees of weight loss (WL). The advent of genomic testing has quantified estimates of both the contribution...

...Annalouise O'Connor; Andrew G. Swick Obesity is a polygenic chronic condition, and dysregulation in multiple underlying energy balance processes drives the obese phenotype. Lifestyle changes can be difficult to sustain long term, and anti-obesity drugs can be an advantageous component...

... study identified genetic predictors of weight change during behavioral weight loss treatment. Methods: Participants were 3,899 overweight/obese individuals with type 2 diabetes from Look AHEAD, a randomized controlled trial to determine the effects of intensive lifestyle intervention (ILI), including...

...Alexis Gorden; Rongze Yang; Laura M. Yerges-Armstrong; Kathleen A. Ryan; Elizabeth Speliotes; Ingrid B. Borecki; Tamara B. Harris; Xin Chu; G. Craig Wood; Christopher D. Still; Alan R. Shuldiner; Glenn S. Gerhard; the GOLD Consortium Objective: Obesity-associated non-alcoholic fatty liver disease...

... of the genes that predispose to obesity in most humans are known. We tested candidate genes in pathways related to food intake and energy expenditure for association with measures of adiposity. Methods: We studied 355 genetic variants in 30 candidate genes in 7 molecular pathways related to obesity in two...

... Swedish subpopulations (regions) with respect to hypercholesterolemia and its possible determinants including dietary factors, obesity and the degree of Finnish genetic influence. A significant regional heterogeneity was found concerning hypercholesterolemia, obesity and high consumption of ‘boiled...

...L.A. Zonta; S.D. Jayakar; M. Bosisio; A. Galante; V. Pennettil An analysis of the genetic factors in obesity has been carried out on a sample of nuclear families from Aosta (N. Italy). The families consisted of the parents and sibs of all elementary school children considered to be obese during...

...Richard R. Fabsitz; Jun-mo Nam; John Gart; Albert Stunkard; Arlen Price; Peter W.F. Wilson A subgroup of 351 subjects with human leukocyte antigen (HLA) typing were available from the Framingham Heart Study for analyses to identify associations with obesity. The subjects consisted of 143 males...

... to overweight or obesity in samples of middle-aged or older individuals. A bivariate analysis demonstrated that, while monozygotic co-twins appeared to be drawn from the same component distributions (normal or overweight), the twin correlations varied across components, with the lowest correlation...

.... Over one-third of sibling environmental similarity was due to non-inherited factors. Cultural inheritance was very strong, tending to mimic genetic inheritance, and cultural heritability was considerable. Measures of obesity were included in the environmental index, an estimate of familial environment...

... whether the CETP gene (Taq1B) polymorphism predisposes to Acute Coronary Syndromes (ACS) depending on obesity status. Methods: We studied demographic, lifestyle and clinical information in 237 hospitalized patients (185 males) with a first event of an ACS and 237 controls matched by age and sex. CETP...

...Dvora Shmulewitz; Steven B. Auerbach; Thomas Lehner; Maude L. Blundell; Jeffrey D. Winick; Linda D. Youngman; Vita Skilling; Simon C. Heath; Jürg Ott; Markus Stoffel; Jan L. Breslow; Jeffrey M. Friedman Objectives: Obesity, type II diabetes, hypertension, and dyslipidemia are major causes...

...R. Arlen Price; Joseph H. Lee We examined age- and sex-standardized risk ratios (SRRs) in matched samples of 1,185 families of obese African-American and Caucasian women. Familial risk ratios increased with body mass index (BMI) of proband and BMI thresholds of relative. Ratios were higher...