... their evolution. We here analyzed in detail HLA genetic variation in Europe in order to identify signatures of migration history and/or natural selection. Methods: Relationships between HLA diversity and geography were analyzed at 7 loci through several approaches including linear regression on gene diversity...

... of natural selection and population-specific demographic history. Methods: Here we characterize the action of natural selection operating across complex disease categories, and use population genetic simulations to evaluate the expected patterns of genetic variation in large samples. We focus on populations...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Viability Fitness Natural selection Hum. Hered. 31: 172-179 (1981) The Relative Viabilities of Alternative Human...

... pregnancy in the study published by Linn and co-workers. This relationship is important from an evolutionary standpoint and it suggests that the natural selection could be working more intensely against Rh(+) than against Rh(–) mothers. 2 02 1994 17 06 1994 3 9 2008 © 1994 S. Karger AG...

... distributions in spontaneously aborted fetuses and liveborn children, which makes differential intrauterine selection unlikely. However, the ethnic and clinal variations suggest that the codon 72 polymorphism is balanced and maintained by natural selection. © 1994 S. Karger AG, Basel 1994 Copyright / Drug...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Birth weight Mortality Natural selection Hum. Hered. 3 4 : 170-173(1984) © 1984 S. Karger AG. Basel 0001 -5652/84...

..., instructions or products referred to in the content or advertisements. Transferrin C subtypes Age effect Natural selection 2 9 2008 Short Communications Hum. Hered. 36: 254-255(1986) © 1986S. Karger AG. Basel 0001-5652/86/0364-0254 S 2.75/0 Decrease of Transferrin C2 Frequency with Age1 L...

... transferrin C2 appears to be associated with reproductive disturbances and with premature birth, but not with birth weight in mature infants. Birth weight Natural selection Transferrin subtypes 2 9 2008 © 1987 S. Karger AG, Basel 1987 Copyright / Drug Dosage / Disclaimer Copyright: All...

...A.V. Millard; E.A. Berlin Natural selective effects of ABO maternofetal incompatibility depend on age, sex and gene frequency. This study focuses on differences of fitness according to age and sex. Calculations of genotype frequencies weighted by fitness lead to the hypothesis that forces...

... is also presented. Birth weight Perinatal mortality Natural selection Selection relaxation Original Papers Hum. Hered. 38: 129-135(1988) © 1988 S. Karger AG. Basel 0001-5652/88/0383-0129 $ 2.75/0 Birth Weight and Natural Selection: An Example of Selection Relaxation in Man1 L. Ulizzi, C. Manzotti...

... and Pl3 alleles were found to be associated with higher rates of fetal loss and various complications of pregnancy. Placental alkaline phosphatase Abortion Stillbirth Natural selection Alkaline phosphatase Hum. Hered. 38: 31-35(1988) © 1988 S. KargcfAG. Basel 000I-5652/88/0381-0031S 2.75/0...

...Bertis B. Little; Robert M. Malina Genetic drift and natural selection were analyzed in a genetically isolated Zapotec-speaking community in the Valley of Oaxaca, southern Mexico. Moderately intense genetic drift and selection potentials were found. Potential for drift was related to (1) the small...

.... Ageing α 1 -antitrypsin Natural selection PI phenotype HumHered 1990;40:22-28 © 1990 S. Karger AG. Basel 0001-5652/90/0401-0022 $ 2.75/0 Alpha-l-Antitrypsin (Protease Inhibitor) Phenotypes and Longevity A. Muir, J.B. Whitfield Department of Clinical Biochemistry. Royal Prince Alfred...

.... Transferrin C subtypes Age effect Natural selection Short Communication Hum Hcretl 1993;43:63-65 A. Du Chesne Department of Legal Medicine, University of Münster, FRG Does the Transferrin C2 Frequency Depend on Age? Key Words Transferrin C subtypes Age effect Natural selection Abstract In a previous...

... × 10 -5 , within expected ranges. During the last 10’ years, family planning and modern treatment with cryoprecipitates have increased the mean age of living hemophiliacs from 12.7 up to 22.7 years, and life expectancy from 15.6 to 22.4 years. Probably relaxation of natural selection will account...

.... Placental phosphatase Allelic variants Leucine inhibition Natural selection Hum. Hered. 30: 18-20 (1980) The 18 Variant of Human Placental Alkaline Phosphatase is Identical to the D-Variant George J. Doellgast, Martha Kennedy and Lynda J. Donald Department of Biochemistry, Bowman Gray School...

... data are presented and analyzed. Natural selection is not acting against the albinism gene at a measurable rate. Cytogenetic investigations among albinos and normals did not reveal any difference as regards frequency of aneuploidy, association of acrocentrics and chromatid gaps. The role of random...

... disequilibrium data in gene mapping in isolated populations, in the estimation of recombination rates and in studying the history of particular alleles, including the detection of natural selection. We discuss current understanding of the extent and patterns of linkage disequilibrium in the genome, and its...