... genotypes · Missing data · Family studies · Family data · Association tests Abstract Background: In longitudinal epidemiological studies there may be individuals with rich phenotype data who die or are lost to follow-up before providing DNA for genetic studies. Often, the genotypic and phenotypic data...

... in several different genes, the most common approach is a complete case analysis, in which only individuals with no missing genotypes are included. But this can lead to substantial reduction in sample size and thus potential bias and loss in efficiency. A number of other methods for handling missing data...

...: April 14, 2009 Published online: July 22, 2009 A New Method to Account for Missing Data in Case-Parent Triad Studies T.L. Bergemanna Z. Huangb aBiostatistics, University of Minnesota, Minneapolis, Minn., and bAbbott Laboratories, Abbott Park, Ill., USA Key Words Log-linear models Case-parent triad...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. FBAT Longitudinal Phenotype Missing Data National Institutes of Health (NIH) 10.13039/100000002 Original...

...Frank Dudbridge Missing data occur in genetic association studies for several reasons including missing family members and uncertain haplotype phase. Maximum likelihood is a commonly used approach to accommodate missing data, but it can be difficult to apply to family-based association studies...

...Yang Yang; Carol A. Wise; Derek Gordon; Stephen J. Finch The purpose of this work is the development of a family-based association test that allows for random genotyping errors and missing data and makes use of information on affected and unaffected pedigree members. We derive the conditional...

... Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands Key Words Coarsening EM-algorithm Fisher information Haplotype Missing data Phase ambiguity Abstract The problem of estimating haplotype frequencies from unphased single nucleotide polymorphism (SNP) genotype...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Disease onset Cancer Missing data Imputation methods Original Paper Hum Hered 2007;63:168 174 DOI: 10.1159...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Family-based study Association Identity-by-state Missing data Maternal-fetal genotype incompatibility Original...

... and nongenetic factors, but that biased inference can result when there is moderate to strong dependence. Overall, the method is found to perform well in the models we considered. Haplotype phase Association study Maximum likelihood EM algorithm Missing data Variance estimates Original Paper Hum Hered...