...M. Knapp; S.A. Seuchter; M.P. Baur It is believed that the main advantage of affected sib-pair tests is that their application requires no information about the underlying genetic mechanism of the disease. However, here it is proved that the mean test, which can be considered the most prominent...

... hypothesis of no linkage. Here, we consider different optimality criteria for sib-pair linkage tests. While for recessive inherited diseases the mean test is found to be uniformly (in Θ) most powerful, it can also be shown that, irrespective of the mode of inheritance, the mean test is the locally optimal...

... I error rate of the single-point Mean test for studies in which genotypes of both parents are available. Methods: Datasets were simulated assuming no linkage and one of five models for genotyping error. In each dataset, Mendelian-inconsistent families were either excluded or regenotyped...

...Michael Knapp Previously, it has been shown for affected sib pairs that the mean test is the uniformly (in Θ) most powerful test in case of a multiplicative mode of inheritance and that the mean test is equivalent to parametric linkage analysis calculated under an assumed multiplicative mode...