...-wide linkage analysis on 5 nuclear and extended families to search for genetic loci that influence the presence of both prodigy and ASD, assuming that the two traits have the same genetic etiology in the analysis model in order to find shared loci. A shared locus on chromosome 1p31-q21 reached genome...

... Blangero; Ravindranath Duggirala; Donna M. Lehman; Christopher P. Jenkinson; Ralph A. DeFronzo Objective: Type 2 diabetes (T2DM) is a complex metabolic disease and is more prevalent in certain ethnic groups such as the Mexican Americans. The goal of our study was to perform a genome-wide linkage (GWL...

... recessive disease-causing variants. In this second step, analogous to homozygosity mapping, a heterogeneity lod-score, HFLOD, is computed to quantify the evidence of linkage provided by the data. In this paper, we evaluate this strategy theoretically under different scenarios and compare its performances...

...Li Ma; Wing Hung Wong; Art B. Owen Background: Linkage and association analysis based on haplotype transmission disequilibrium can be more informative than single marker analysis. Several works have been proposed in recent years to extend the transmission disequilibrium test (TDT) to haplotypes...

...Veronica J. Vieland; Yungui Huang; Sang-Cheol Seok; John Burian; Umit Catalyurek; Jeffrey O’Connell; Alberto Segre; William Valentine-Cooper This paper describes the software package KELVIN, which supports the PPL (posterior probability of linkage) framework for the measurement of statistical...

...Joan E. Bailey-Wilson; Alexander F. Wilson Linkage analysis was developed to detect excess co-segregation of the putative alleles underlying a phenotype with the alleles at a marker locus in family data. Many different variations of this analysis and corresponding study design have been developed...

... and type 2 diabetes. We conducted a genome-wide linkage screen to identify susceptibility genes influencing systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Mexican-Americans from the Veterans Administration Genetic Epidemiology Study (VAGES). Methods: Using data from 1,089 individuals...

..., the sample will, with high probability, contain ‘non-segregating’ families, i.e. families with both parents homozygous at the QTL. These families potentially reduce the power of regression-based methods to detect linkage. Moreover, follow-up studies in individual families will be inefficient, and potentially...

... Monte-Carlo simulation study Linkage Type I error Empirical power Original Paper Hum Hered 2010;69:202 211 DOI: 10.1159/000289596 Received: June 1, 2009 Accepted after revision: December 21, 2009 Published online: March 5, 2010 An Extensive Comparison of Quantitative Trait Loci Mapping Methods...

...Ruzong Fan; Joanna Floros; Momiao Xiong In this paper, we explore models and tests for association and linkage studies of a quantitative trait locus (QTL) linked to a multi-allele marker locus. Based on the difference between an offspring’s conditional trait means of receiving and not receiving...

...; Consuelo Valencia-Ramirez; Mauricio Arcos-Burgos Objectives: Non-syndromic orofacial clefts, i.e. cleft lip (CL) and cleft palate (CP), are among the most common birth defects. The goal of this study was to identify genomic regions and genes for CL with or without CP (CL/P). Methods: We performed linkage...

...Yanming Di; Elizabeth A. Thompson Background/Aims: With pedigree data, genetic linkage can be detected using inheritance vector tests, which explore the discrepancy between the posterior distribution of the inheritance vectors given observed trait values and the prior distribution...

... genomes project, greatly reduces the errors due to finite sample size for a large proportion of SNPs. Linkage HapMap Finite sample error Association studies National Institutes of Health (NIH) 10.13039/100000002 11 09 2008 12 11 2008 9 4 2009 © 2009 S. Karger AG...

...Hui Wang; Jan H. Veldink; Hylke Blauw; Leonard H. van den Berg; Roel A. Ophoff; Chiara Sabatti Background/Aims: Illumina genotyping arrays provide information on DNA copy number. Current methodology for their analysis assumes linkage equilibrium across adjacent markers. This is unrealistic, given...

... association Family history Sib methods Linkage Gc serum groups Schizophrenia Original Papers Hum. Hered.36: 89-92(1986) © 1986 S. Karger AG. Basel 0001-5652/86/0362-0089 $ 2.75/0 Heterogeneity in Disease Associations O. Mayo, Deborah J. Street Biometry Section, Waite Agricultural Research Institute...

... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Linkage FASTMAP Original Paper Hum Hered...

.... Thirty-five multiplex families from the mid-Atlantic region of the United States and 22 families from central Mexico with a nonsyndromic form of cleft lip with or without cleft palate were selected for a linkage analysis. A tetranucleotide repeat marker (D2S443) located on the same yeast artificial...

...Jennifer E. Reynolds; Kathleen S. Arnos; Barbara Landa; Cathy A. Stevens; Bonnie A. Salbert; Laura Wright; Bettie Duke; Wanda Hunt; Mary L. Marazita; Lynn Ploughman; Charles MacLean; Walter E. Nance; Scott R. Diehl We performed linkage and locus heterogeneity analyses of Waardenburg syndrome (WS...

...A. Collins; N.E. Morton Sib pair tests for linkage to a quantitative trait or affection status are examined by simulation. A sibship of size s contributes only s – 1 independent sib pairs but all s(s – 1)/2 pairs are needed for an efficient test. Redundancy increases with sibship size. Using...

.... Phenylthiocarbamide Diabetes Linkage Bangladesh Original Paper Hum Hered 1994;44:14-17 S.G.M. Ali* A.K. Azad Khan* H. Mahtaha A.R. Khan* M. Muhihullahb Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM). Ibrahim Memorial Diabetes Centre, and Institute...