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Keywords: Linkage
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Journal Articles
Subject Area:
Genetics
Hum Hered (2015) 79 (2): 53–59.
Published Online: 10 March 2015
...-wide linkage analysis on 5 nuclear and extended families to search for genetic loci that influence the presence of both prodigy and ASD, assuming that the two traits have the same genetic etiology in the analysis model in order to find shared loci. A shared locus on chromosome 1p31-q21 reached genome...
Journal Articles
Journal Articles
Subject Area:
Genetics
Hum Hered (2013) 74 (3-4): 142–152.
Published Online: 11 April 2013
... recessive disease-causing variants. In this second step, analogous to homozygosity mapping, a heterogeneity lod-score, HFLOD, is computed to quantify the evidence of linkage provided by the data. In this paper, we evaluate this strategy theoretically under different scenarios and compare its performances...
Journal Articles
Subject Area:
Genetics
Hum Hered (2012) 73 (1): 52–61.
Published Online: 02 March 2012
...Li Ma; Wing Hung Wong; Art B. Owen Background: Linkage and association analysis based on haplotype transmission disequilibrium can be more informative than single marker analysis. Several works have been proposed in recent years to extend the transmission disequilibrium test (TDT) to haplotypes...
Journal Articles
Subject Area:
Genetics
Hum Hered (2011) 72 (4): 228–236.
Published Online: 23 December 2011
...Joan E. Bailey-Wilson; Alexander F. Wilson Linkage analysis was developed to detect excess co-segregation of the putative alleles underlying a phenotype with the alleles at a marker locus in family data. Many different variations of this analysis and corresponding study design have been developed...
Journal Articles
Subject Area:
Genetics
Hum Hered (2011) 72 (4): 276–288.
Published Online: 23 December 2011
...Veronica J. Vieland; Yungui Huang; Sang-Cheol Seok; John Burian; Umit Catalyurek; Jeffrey O’Connell; Alberto Segre; William Valentine-Cooper This paper describes the software package KELVIN, which supports the PPL (posterior probability of linkage) framework for the measurement of statistical...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Genetics
Hum Hered (2010) 69 (3): 202–211.
Published Online: 05 March 2010
... Monte-Carlo simulation study Linkage Type I error Empirical power Original Paper Hum Hered 2010;69:202 211 DOI: 10.1159/000289596 Received: June 1, 2009 Accepted after revision: December 21, 2009 Published online: March 5, 2010 An Extensive Comparison of Quantitative Trait Loci Mapping Methods...
Journal Articles
Journal Articles
Subject Area:
Genetics
Hum Hered (2002) 53 (3): 130–145.
Published Online: 11 June 2009
...Ruzong Fan; Joanna Floros; Momiao Xiong In this paper, we explore models and tests for association and linkage studies of a quantitative trait locus (QTL) linked to a multi-allele marker locus. Based on the difference between an offspring’s conditional trait means of receiving and not receiving...
Journal Articles
Subject Area:
Genetics
Hum Hered (2009) 68 (2): 139–150.
Published Online: 11 May 2009
...Yanming Di; Elizabeth A. Thompson Background/Aims: With pedigree data, genetic linkage can be detected using inheritance vector tests, which explore the discrepancy between the posterior distribution of the inheritance vectors given observed trait values and the prior distribution...
Journal Articles
Subject Area:
Genetics
Hum Hered (2009) 68 (2): 73–86.
Published Online: 09 April 2009
... genomes project, greatly reduces the errors due to finite sample size for a large proportion of SNPs. Linkage HapMap Finite sample error Association studies National Institutes of Health (NIH) 10.13039/100000002 11 09 2008 12 11 2008 9 4 2009 © 2009 S. Karger AG...
Journal Articles
Subject Area:
Genetics
Hum Hered (2009) 68 (1): 1–22.
Published Online: 01 April 2009
...Hui Wang; Jan H. Veldink; Hylke Blauw; Leonard H. van den Berg; Roel A. Ophoff; Chiara Sabatti Background/Aims: Illumina genotyping arrays provide information on DNA copy number. Current methodology for their analysis assumes linkage equilibrium across adjacent markers. This is unrealistic, given...
Journal Articles
Subject Area:
Genetics
Hum Hered (1986) 36 (2): 89–92.
Published Online: 04 September 2008
... association Family history Sib methods Linkage Gc serum groups Schizophrenia Original Papers Hum. Hered.36: 89-92(1986) © 1986 S. Karger AG. Basel 0001-5652/86/0362-0089 $ 2.75/0 Heterogeneity in Disease Associations O. Mayo, Deborah J. Street Biometry Section, Waite Agricultural Research Institute...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Genetics
Hum Hered (1995) 45 (4): 199–205.
Published Online: 03 September 2008
... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Linkage FASTMAP Original Paper Hum Hered...
Journal Articles
Journal Articles
Subject Area:
Genetics
Hum Hered (1995) 45 (6): 311–318.
Published Online: 03 September 2008
...A. Collins; N.E. Morton Sib pair tests for linkage to a quantitative trait or affection status are examined by simulation. A sibship of size s contributes only s – 1 independent sib pairs but all s(s – 1)/2 pairs are needed for an efficient test. Redundancy increases with sibship size. Using...