... information. Methods: The main challenge is to accurately and rapidly evaluate the significance for millions of SNPs. We propose methods for approximating p values by correcting for the multiple testing introduced by testing many distance matrices and by correcting for the skewness and kurtosis of score...

... repeated the same simulations using a larger sample size (200 sib pairs) and found similar results. 7 01 2003 1 9 2003 Box-Cox transformation Kurtosis Sib pair linkage analysis Skewness Non-normality Winsorizing Original Paper Hum Hered 2003;55:108 116 DOI: 10.1159/000072315...