... heritabilities, main effects of GRS and birth year, GRS-by-birth year interaction, sex, and age. Results: Positive GRS-by-birth year interaction effects were found for BMI (p < 0.001), waist circumference (p = 0.007), and skinfold thickness (p < 0.007). For example, each one-allele increase in GRS...

...) to assess the ability of haplotypic analysis to identify functional interactions between SNPs at the same locus. We found that, when phase is known, analysis of the haplotype is more powerful than analysis of the individual SNPs. The difference between the two approaches becomes less either as an increasing...

...Xuefeng Wang; Robert C. Elston; Xiaofeng Zhu Although recent studies have attempted to dispel the confusion that exists in regard to the definition, analysis and interpretation of interaction in genetics, there still remain aspects that are poorly understood by non-statisticians. After a brief...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Hp types ABO groups Segregation distortion Interaction Human Heredity 24 : 45-52 (1974) A Segregation Analysis of the Association of Haptoglobin Types and ABO Blood Groups J. L. MacDonald and S...

...) in DNA repair genes have been reported to modify bladder cancer risk. These include: APE1- Asn148Gln, XRCC1- Arg399Gln and XRCC1- Arg194Trp in the BER pathway, XPD- Gln751Lys in the NER pathway and XRCC3- Thr241Met in the DSB repair pathway. Methods: To examine the independent and interacting effects...

...Daniel J. Schaid; Jason P. Sinnwell; Stephen N. Thibodeau Background/Aims: Genetic linkage analysis of common diseases is complicated by the heterogeneity of genetic and environmental factors that increase disease risk, and possibly interactions among them. Most linkage methods that account...

...Sara C. Hamon; Sharon L.R. Kardia; Eric Boerwinkle; Kiang Liu; Kathy L.E. Klos; Andrew G. Clark; Charles F. Sing Objective: Evaluate the consistency of the contribution of interactions between single nucleotide polymorphism (SNP) genotype effects to variation in measures of lipid metabolism across...

... Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, Bonn, Germany Key Words Linkage analysis W Complex traits W Locus heterogeneity W Genotype-phenotype relation W Two-locus models W Epistasis W Interaction Abstract Complex traits are often governed by more than one trait...

...Peter Holmans Interest has recently focussed on allowing for interactions between loci as a way to increase power to detect linkage. In this paper, a simplified logistic regression method was used to perform affected sib pair analyses allowing for the inclusion of data from other loci. A systematic...

...W. James Gauderman; Kimberly D. Siegmund Objectives: Gene-environment (G×E) interaction influences risk for many complex disease traits. However, genome screens using affected sib pair linkage techniques are typically conducted without regard for G×E interaction. We propose a simple extension...