..., and Central and South Asian non-Jewish populations in short ROH patterns, relative lengths of identity-by-descent tracts in different Jewish groups, and the “population isolate” status of the Ashkenazi Jews. jtlkang@stanford.edu 4 01 2017 14 06 2017 15 9 2017 © 2017 S. Karger AG...

...Trevor J. Pemberton; Noah A. Rosenberg Background/Aims: Culturally driven marital practices provide a key instance of an interaction between social and genetic processes in shaping patterns of human genetic variation, producing, for example, increased identity by descent through consanguineous...

... types of relative pairs is also discussed. The models may be used in genome scanning and in studying single or multilocus models of inheritance. Identity by descent Gene mapping Two-locus models Multipoint Variance components © 1997 S. Karger AG, Basel 1997 Copyright / Drug Dosage...

... realizations from the distribution of gene identity by descent ( ibd ) patterns on a pedigree, conditional on observed data Y M at multiple marker loci. Measures of gene ibdW which capture joint genome sharing in extended pedigrees often have unknown and highly skewed distributions, particularly when...

...Chris Cannings The probabilities of the various possible identity by descent (IBD) states at a locus captures all the genealogical information for that locus for the set of individuals under consideration. Here we study the stochastic process of the IBD state as one moves across the genome of a set...

.... Identity by descent Power Original Paper Hum Hered 2003;55:153 162 DOI: 10.1159/000073199 Received: February 18, 2003 Accepted: May 16, 2003 Statistical Properties of Affected Sib-Pair Linkage Tests Chih-Chieh Wu Christopher I. Amos Department of Epidemiology, The University of Texas M.D. Anderson...

... at the 0.05 level after correcting for simultaneous testing of multiple loci. The study demonstrates the efficiency of our novel strategy to detect identity by descent (IBD) in small numbers of patients and controls when they are both part of well-defined Mendelian breeding units (MBUs). The iterative...

...Eric Sobel; Haydar Sengul; Daniel E. Weeks Objectives: To describe, implement, and test an efficient algorithm to obtain multipoint identity-by-descent (IBD) probabilities at arbitrary positions among marker loci for general pedigrees. Unlike existing programs, our algorithm can analyze data sets...

... position. On the other hand, allele-sharing methods, as currently practiced, are designed to test the null hypothesis of no linkage rather than estimate the location of the susceptibility gene(s). In this paper, we propose an identity-by-descent (IBD)-based procedure to estimate the location...

... at both loci, the expected joint identity-by-descent (IBD) probabilities, and the correlation between marginal IBD probabilities at the two loci. These studies are useful for linkage analyses using single-locus models while the underlying disease model is two-locus, and for correlation analyses using...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Haplotype relative risk Identity by descent Linkage analysis Linkage disequilibrium...

.... Psoriasis Genetic linkage HLA-B HLA association Linkage disequilibrium Identity by descent Two-locus models Heterogeneity Figure  1 shows the haplotype-based lod score curves for 6 of the 10 dominant models we examined and for all 6 recessive models. Table  2 gives Z max and θcirc; for each...