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Keywords: Hidden Markov random field
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Journal Articles

Inferring Gene-Disease Association by an Integrative Analysis of eQTL Genome-Wide Association Study and Protein-Protein Interaction Data

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Subject Area:
Genetics
Jun Wang, Jiashun Zheng, Zengmiao Wang, Hao Li, Minghua Deng
Journal: Human Heredity
Hum Hered (2019) 83 (3): 117–129.
https://doi.org/10.1159/000489761
Published Online: 22 January 2019
... approaches, we have developed a statistical framework to integrate information from GWAS, eQTL, and protein-protein interaction (PPI) data to predict disease-associated genes. Our approach is based on a hidden Markov random field (HMRF) model, and we called the resulting computational algorithm GeP-HMRF...
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