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Keywords: Heritability
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Journal Articles
Subject Area:
Genetics
Hum Hered (2022) 87 (1): 12–20.
Published Online: 30 November 2021
... is unknown for breast and prostate cancer. Method: We estimated the relative risks, heritability, and genetic correlation of breast cancer and prostate cancer based on the Minnesota Breast and Prostate Cancer Study, a family study of 141 families ascertained for breast cancer. Results: Heritability of breast...
Journal Articles
Journal Articles
Subject Area:
Genetics
Hum Hered (2018) 83 (2): 92–99.
Published Online: 02 November 2018
... of heritability and linkage. Methods: Statistical theory for the power of variance component analysis of quantitative traits is used to determine the expected contribution of an inbred singleton to likelihood-ratio tests of heritability and linkage. Results: In variance component models, an inbred singleton...
Journal Articles
Subject Area:
Genetics
Hum Hered (2016) 80 (4): 196–206.
Published Online: 01 September 2016
... model in contemporary human genetics: association testing (pathways analysis or rare variants association tests), genomic heritability estimates, and correction for population stratification in genome-wide association studies. We also consider the performance of best linear unbiased predictors...
Journal Articles
Hum Hered (2016) 80 (4): 171–177.
Published Online: 01 April 2015
...Emmanuelle Génin; Françoise Clerget-Darpoux Most studies on multifactorial diseases are performed under the assumption of a polygenic additive liability. In particular, missing heritability and individual risk scores are estimated under this model. In this paper, we use the example of diabetes...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Genetics
Hum Hered (2011) 72 (2): 133–141.
Published Online: 11 October 2011
... are known to affect the immune response, the influence of genetic factors on antibody levels to common infectious agents is largely unknown. Here we test whether antibody levels for 13 common infections are significantly heritable. Methods: IgG antibodies to Chlamydophila pneumoniae , Helicobacter pylori...
Journal Articles
Journal Articles
Subject Area:
Genetics
Hum Hered (2009) 68 (4): 243–251.
Published Online: 22 July 2009
...Claus Thorn Ekstrøm Heritability measures the familial aggregation of a disease or trait and a non-zero heritability suggests that a genetic component may be present. Reliable heritability estimates are necessary in the planning phase of a linkage or genetic association study but often...
Journal Articles
Subject Area:
Genetics
Hum Hered (2008) 67 (1): 38–45.
Published Online: 17 October 2008
... in the development of COPD among AAT deficient subjects. To investigate familial aggregation of lung function in subjects with AAT deficiency, we estimated heritability for forced expiratory volume in 1 s (FEV 1 ) and FEV 1 /forced vital capacity (FVC) in 378 AAT deficient subjects from 167 families in the AAT...
Journal Articles
Subject Area:
Genetics
Hum Hered (1994) 44 (6): 305–311.
Published Online: 03 September 2008
... of the path model. We have presented explicit solutions for path coefficients in terms of the residual correlations. These methods were applied to a French-Canadian family study on body mass index. It was found that the estimate of pseudopolygenic heritability was robust under class A (t 2 = 0.28) and class D...
Journal Articles
Subject Area:
Genetics
Hum Hered (1984) 34 (6): 348–357.
Published Online: 02 September 2008
... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Heritability Migration Selection...
Journal Articles
Subject Area:
Genetics
Hum Hered (1987) 37 (6): 349–353.
Published Online: 02 September 2008
... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Sweat pores Hair density Tooth size Heritability Genetic correlation Hum. Hered. 37...
Journal Articles
Journal Articles
Subject Area:
Genetics
Hum Hered (1983) 33 (5): 277–286.
Published Online: 02 September 2008
...L. Iselius; N.E. Morton; D.C. Rao Familial correlations are available for individuals reared by biological and foster parents, with and without indices of relevant environment. Five data sets give estimates of genetic heritability which range from 0.194 to 0.360 for systolic pressure and from 0.147...
Journal Articles
Subject Area:
Genetics
Hum Hered (1983) 33 (5): 311–318.
Published Online: 02 September 2008
...P. Darlu; J.M. Lalouel; J.G. Henrotte; D.C. Rao Red blood cell zinc levels vary linearly with age within each sex. Age- and sex-adjusted zinc levels generated 6 familial correlations in nuclear families and twins. A simple additive polygenic model, with genetic heritability of zinc (h 2...
Journal Articles
Subject Area:
Genetics
Hum Hered (1990) 40 (4): 235–241.
Published Online: 02 September 2008
... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Blood pressure Family studies Unified model Segregation analysis Heritability Hum Hered 1990:40:235-241 Evidence...
Journal Articles
Subject Area:
Genetics
Hum Hered (1980) 30 (6): 350–356.
Published Online: 29 August 2008
..., instructions or products referred to in the content or advertisements. Segregation analysis Mixed genetic model Schizophrenia Likelihood ratio test Heritability Polyethnic Hum. Hered. 30: 350-356 (1980) Segregation Analysis of Schizophrenia under a Mixed Genetic Model C. L. Carter and C. S. Chung...
Journal Articles
Subject Area:
Genetics
Hum Hered (1980) 30 (2): 112–118.
Published Online: 29 August 2008
... sibling correlations yielded broad heritability estimates (H B ) of 0.50 for endomorphy, 0.42 for mesomorphy and 0.54 for ectomorphy. Narrow heritability (H N ) for ectomorphy, controlling for familial indicators, was approximately 0.36 including a positive contribution from assortative mating. 29 8...