... is unknown for breast and prostate cancer. Method: We estimated the relative risks, heritability, and genetic correlation of breast cancer and prostate cancer based on the Minnesota Breast and Prostate Cancer Study, a family study of 141 families ascertained for breast cancer. Results: Heritability of breast...

...Michael J. Bray; Lea K. Davis; Eric S. Torstenson; Sarah H. Jones; Todd L. Edwards; Digna R. Velez Edwards Background: Heritability estimates (including twin and single nucleotide polymorphism [SNP]-based heritability studies) for fibroids have been inconsistent across prior studies ranging between...

... of heritability and linkage. Methods: Statistical theory for the power of variance component analysis of quantitative traits is used to determine the expected contribution of an inbred singleton to likelihood-ratio tests of heritability and linkage. Results: In variance component models, an inbred singleton...

... model in contemporary human genetics: association testing (pathways analysis or rare variants association tests), genomic heritability estimates, and correction for population stratification in genome-wide association studies. We also consider the performance of best linear unbiased predictors...

...Emmanuelle Génin; Françoise Clerget-Darpoux Most studies on multifactorial diseases are performed under the assumption of a polygenic additive liability. In particular, missing heritability and individual risk scores are estimated under this model. In this paper, we use the example of diabetes...

... heritabilities, main effects of GRS and birth year, GRS-by-birth year interaction, sex, and age. Results: Positive GRS-by-birth year interaction effects were found for BMI (p < 0.001), waist circumference (p = 0.007), and skinfold thickness (p < 0.007). For example, each one-allele increase in GRS...

.../000332824 Received: June 7, 2011 Accepted after revision: September 6, 2011 Published online: October 25, 2011 Missing Heritability in the Tails of Quantitative Traits? A Simulation Study on the Impact of Slightly Altered True Genetic Models Carolin Püttera Sonali Pechlivanisa Markus M. Nöthenb, c Karl...

... are known to affect the immune response, the influence of genetic factors on antibody levels to common infectious agents is largely unknown. Here we test whether antibody levels for 13 common infections are significantly heritable. Methods: IgG antibodies to Chlamydophila pneumoniae , Helicobacter pylori...

... Antihypertensive medication Genetic location Heritability Abstract Objective: Hypertension or high blood pressure is a strong correlate of diseases such as obesity and type 2 diabetes. We conducted a genome-wide linkage screen to identify susceptibility genes influencing systolic blood pressure (SBP...

...Claus Thorn Ekstrøm Heritability measures the familial aggregation of a disease or trait and a non-zero heritability suggests that a genetic component may be present. Reliable heritability estimates are necessary in the planning phase of a linkage or genetic association study but often...

... in the development of COPD among AAT deficient subjects. To investigate familial aggregation of lung function in subjects with AAT deficiency, we estimated heritability for forced expiratory volume in 1 s (FEV 1 ) and FEV 1 /forced vital capacity (FVC) in 378 AAT deficient subjects from 167 families in the AAT...

... of the path model. We have presented explicit solutions for path coefficients in terms of the residual correlations. These methods were applied to a French-Canadian family study on body mass index. It was found that the estimate of pseudopolygenic heritability was robust under class A (t 2 = 0.28) and class D...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Blood pressure Family studies Unified model Segregation analysis Heritability Hum Hered 1990:40:235-241 Evidence...

... or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Sweat pores Hair density Tooth size Heritability Genetic correlation Hum. Hered. 37...

... and the hyperlipidemic samples is detected in the multifactorial transmission for TG and HDL, and moderate heterogeneity is detected for CH and LDL, with a pattern of higher genetic heritability estimates in the random than nonrandom samples. The observed pattern of heterogeneity is compatible with a higher prevalence...

...L. Iselius; N.E. Morton; D.C. Rao Familial correlations are available for individuals reared by biological and foster parents, with and without indices of relevant environment. Five data sets give estimates of genetic heritability which range from 0.194 to 0.360 for systolic pressure and from 0.147...

...P. Darlu; J.M. Lalouel; J.G. Henrotte; D.C. Rao Red blood cell zinc levels vary linearly with age within each sex. Age- and sex-adjusted zinc levels generated 6 familial correlations in nuclear families and twins. A simple additive polygenic model, with genetic heritability of zinc (h 2...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Heritability Migration Selection...

... to observed variances. Maximum likelihood analysis showed that genetic or threptic contribution alone was unable to fit the data, and the best fit was given by a parsimonious form of MAVA dropping genothreptic correlations. Population heritabilities calculated on this basis were 0.46 for UI 16 (ego assertion...

...Alvaro Rodríguez; Ranajit Chakraborty; William J. Schull A Monte Carlo simulation is performed to study the distribution of the family set estimators of heritability and to compare their performance with that of some conventional estimators used in human genetics. Comparisons of statistical...