...Zhitao Li; Xinyu Sun; Jia He; Dongyan Kong; Jinyi Wang; Lili Wang Introduction: Schizophrenia (SCZ), a severe neuropsychiatric disorder with high genetic susceptibility, has high rates of misdiagnosis due to the unavoidably subjective factors and heterogeneous clinical presentations. Hypoxia has...

... R. Shaffer; Steven E. Reis; Seth M. Weinberg; Katherine Neiswanger; Daniel W. McNeil; Mary L. Marazita Introduction: Enamel hypoplasia causes a reduction in the thickness of affected enamel and is one of the most common dental anomalies. This defect is caused by environmental and/or genetic factors...

...-wide linkage analysis on 5 nuclear and extended families to search for genetic loci that influence the presence of both prodigy and ASD, assuming that the two traits have the same genetic etiology in the analysis model in order to find shared loci. A shared locus on chromosome 1p31-q21 reached genome...

... and anterior segment anomalies remain elusive. The majority of genes implicated thus far act in an autosomal dominant manner. Autosomal recessive causes are less well described; their diagnosis has been hindered by technological limitations, extreme genetic heterogeneity, a lack of understanding of eye biology...

... was found. Conclusion: Our findings suggest that consanguinity might increase the risk of T2D by an earlier onset of the disease and by strengthening possible genetic effects on FBG. [email protected] 29 7 2014 © 2014 S. Karger AG, Basel 2014 Copyright / Drug Dosage / Disclaimer...

...Jeanne M. McCaffery; George D. Papandonatos; Gordon S. Huggins; Inga Peter; Bahar Erar; Steven E. Kahn; William C. Knowler; Edward W. Lipkin; Abbas E. Kitabchi; Lynne E. Wagenknecht; Rena R. Wing; The Genetic Subgroup of Look AHEAD and The Look AHEAD Research Group Background/Aims: The present...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Genetic heterogeneity Genetics...

.... Linkage Genetics DNA sequence Whole-exome sequence Whole-genome sequence National Institutes of Health (NIH) 10.13039/100000002 Hum Hered 2011;72:228 236 DOI: 10.1159/000334381 Published online: December 23, 2011 Linkage Analysis in the Next-Generation Sequencing Era Joan E. Bailey...

...Rohina Rubicz; Charles T. Leach; Ellen Kraig; Nikhil V. Dhurandhar; Ravindranath Duggirala; John Blangero; Robert Yolken; Harald H.H. Göring Background/Aims: Antibodies against infectious pathogens provide information on past or present exposure to infectious agents. While host genetic factors...

...Ann M. Madsen; Susan E. Hodge; Ruth Ottman Background/Aims: To illustrate the utility of causal models for research in genetic epidemiology and statistical genetics. Causal models are increasingly applied in risk factor epidemiology, economics, and health policy, but seldom used in statistical...

... to models of causation . Methods: We describe a sufficient component cause model for a hypothetical disease with two genetic causes. We then use the potential outcomes framework to determine the expected two-locus penetrances from this causal model and contrast them with commonly used two-locus penetrance...

...Derek Gordon; Stephen J. Finch; Francisco De La Vega Genome-wide association studies (GWAS) have been successful in identifying common genetic variation reproducibly associated with disease. However, most associated variants confer very small risk and after meta-analysis of large cohorts a large...

...: These results highlight the importance of careful phenotypic delineation in large samples of families for genetic analyses of complex, heterogeneous traits such as CL/P. 2 12 2008 12 02 2009 11 6 2009 Original Paper Hum Hered 2009;68:151 170 DOI: 10.1159/000224636 Received: December 2, 2008...

... Tasha E. Fingerlina Deborah H. Gluecka aDepartment of Preventive Medicine and Biometrics, University of Colorado Denver, Denver, Colo., and bThe Cholesterol Center, Jewish Hospital, Cincinnati, Ohio, USA Key Words PAI-1 Pregnancy loss Thrombophilia Hypofibrinolysis Genetics cal method can...

...Fabio Macciardi; Massimiliano Verga; James L. Kennedy; Arturas Petronis; Giuseppe Bersani; Paolo Pancheri; Enrico Smeraldi Our work investigates the relationship between genetic factors and schizophrenia, seeking to identify a gene or genes associated with the clinical form of the disease...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. α-Thalassemia Genetics Human Heredity Original Paper Hum...

... and sufficient conditions seem to have escaped the notice of previous statistical geneticists. Descartes’ rule of signs Genetics Linkage analysis Linkage phase Lod score Maximum likelihood Recombination © 1996 S. Karger AG, Basel 1996 Copyright / Drug Dosage / Disclaimer Copyright...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Autism Fragile X Genetics...

...H. King; D.C. Rao; K. Bhatia; G. Koki; A. Collins; P. Zimmet Path analysis of family resemblance for plasma glucose concentration, 2 h after an oral glucose challenge, failed to detect significant genetic heritability. There were no intergenerational differences and marital resemblance was moderate...

... and 6.5 × 10 9 /l. The evidence of two or three phenotypes, although consistent with the effect of a single-factor hypothesis (genetic or environmental), must be confirmed by segregation analysis of families. Hum Hered 1989;39:240-247 © 1989 S. Karger AG. Basel 0001-5652/89/0394-0240 $ 2.75/0 Regulation...