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Keywords: Gene-set association
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Journal Articles
Beyond GWAS in COPD: Probing the Landscape between Gene-Set Associations, Genome-Wide Associations and Protein-Protein Interaction Networks
Available to PurchaseSubject Area:
Genetics
Merry-Lynn Noelle McDonald, Manuel Mattheisen, Michael H. Cho, Yang-Yu Liu, Benjamin Harshfield, Craig P. Hersh, Per Bakke, Amund Gulsvik, Christoph Lange, Terri H. Beaty, Edwin K. Silverman, on behalf of the GenKOLS, COPDGene and ECLIPSE study investigators
Journal:
Human Heredity
Hum Hered (2015) 78 (3-4): 131–139.
Published Online: 27 August 2014
... approach to integrate genotype and protein-protein interaction (PPI) data to identify disease network modules associated with chronic obstructive pulmonary disease (COPD) and to perform traditional pathway analysis. Methods: We utilized a standard gene-set association approach (FORGE) using gene-based...