... hippocampal volume data in 6 h per data set, while current single CPU-based approaches require more than a year’s time to complete the same task. Epistasis Genome-wide interaction analysis Computational biology Graphics processing units Original Paper Hum Hered 2012;73:220 236 DOI: 10.1159/000341885...

... of heterogeneity, and KELVIN itself utilizes sophisticated software engineering to provide a powerful and robust platform for studying the genetics of complex disorders. 23 12 2011 Association Covariates Epistasis Imprinting Linkage Linkage disequilibrium Quantitative traits Software KELVIN...

... between the traits. The inclusion of multiple quantitative trait loci in linkage analysis allows the inference of epistasis between loci. A user-friendly graphical user interface facilitates the usage of jPAP. 23 12 2011 © 2011 S. Karger AG, Basel 2011 Copyright / Drug Dosage / Disclaimer...

..., Minneapolis, Minn., USA Key Words Complex traits Epistasis Logistic regression Adaptive Neyman test Simulation SSU test Sum test UminP test Abstract There has been an increasing interest in detecting genegene and gene-environment interactions in genetic association studies. A major statistical...

... of observed data. Conclusion: Causal models can enhance research aimed at identifying causal genes. Additive models Causal models Multiplicative models Epidemiology Genetics Heterogeneity models Epistasis Penetrance National Institutes of Health (NIH) 10.13039/100000002 Original...

... to in the content or advertisements. Causal models Epidemiology Genetics Two-locus models Penetrance Additive models Heterogeneity models Multiplicative models Epistasis National Institutes of Health (NIH) 10.13039/100000002 Original Paper Hum Hered 2011;72:63 72 DOI: 10.1159/000330780...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Epistasis Gametic phase disequilibrium Interaction Transformation National Institutes of Health (NIH) 10.13039/100000002 Original Paper Hum Hered 2010;70:269 277 DOI...

...Jiang Gui; Angeline S. Andrew; Peter Andrews; Heather M. Nelson; Karl T. Kelsey; Margaret R. Karagas; Jason H. Moore Epistasis or gene-gene interaction is a fundamental component of the genetic architecture of complex traits such as disease susceptibility. Multifactor dimensionality reduction (MDR...

.... Epistasis Genome-wide association study Logistic regression Main-effects model Score test SNP Sum of squared score tests National Institutes of Health (NIH) 10.13039/100000002 Original Paper Hum Hered 2010;69:131 142 DOI: 10.1159/000264450 Received: May 12, 2009 Accepted after revision...

... by the Cochran-Armitage method and (2) the allelic based method provides higher power than two genotypic based methods. Allelic test Interaction effect Score test Cochran-Armitage method Epistasis Original Paper Hum Hered 2010;69:14 27 DOI: 10.1159/000243150 Received: November 24, 2008 Accepted after...

...Alexandre Bureau; Chantal Mérette; Jordie Croteau; Alain Fournier; Yvon C. Chagnon; Marc-André Roy; Michel Maziade Background/Aims: Epistasis, the biological interaction of multiple genes modulating their individual effects, is likely omnipresent in complex diseases, and modelling epistasis...

... Epistasis MDR Heterogeneity Original Paper Hum Hered 2009;67:183 192 DOI: 10.1159/000181157 Received: May 2, 2008 Accepted after revision: July 1, 2008 Published online: December 15, 2008 Exploring the Performance of Multifactor Dimensionality Reduction in Large Scale SNP Studies and in the Presence...

... Institute, and Mt. Sinai Medical Center, New York, N.Y., USA Adequacy of Single-Locus Approximations for Linkage Analyses of Oligogenic Traits: Extension to Multigenerational Pedigree Structures Key Words Linkage analysis Two-locus models Epistasis Reduced penetrance Simulation Extended pedigrees Abstract...

... multiplicative, and six were epistasis models. For each situation, the choice for a statistical model was based on global model fit as judged by two different information criteria, the BIC and the AIC. Results: Both methods failed in most of the scenarios to capture the gene-gene interaction present...

... that is recognized as the ‘best’ for detecting, characterizing, and interpreting gene × gene interactions. Instead, a combination of approaches with the aim of balancing their specific strengths may be the optimal approach to investigate gene × gene interactions in human data. Epistasis Genome-wide association...

... Medicine, and bDivision of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, Mo., USA Key Words Epistasis Gene-gene interactions Multilocus traits Association studies Abstract Background/Aims: Many diseases important to public health are not due solely to a single...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Multi-locus Genotype Association mapping Case-control design Complex traits Epistasis National Institutes of Health (NIH) 10.13039/100000002 Original Paper Hum Hered...

..., University of Texas Health Science Center, Houston, Tex.; dDepartment of Preventive Medicine, Northwestern University, Chicago, Ill.; eDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, N.Y., USA Key Words Cholesterol Interaction Epistasis APOA1/C3/A4/A5 gene cluster...

.... Epistasis Hypertension Blacks Renin-angiotensin system Original Paper Hum Hered 2004;57:28 38 DOI: 10.1159/000077387 Received: August 28, 2003 Accepted after revision: December 8, 2003 Multilocus Analysis of Hypertension: A Hierarchical Approach Scott M. Williams a, b, c, d Marylyn D. Ritchie a John...

... estimates of the disease-locus positions. Linkage analysis Complex traits Locus heterogeneity Genotype-phenotype relation Two-locus models Epistasis Interaction 31 10 2002 1 07 2003 25 3 2004 © 2003 S. Karger AG, Basel 2004 Copyright / Drug Dosage / Disclaimer Copyright...