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Journal Articles

Beyond GWAS in COPD: Probing the Landscape between Gene-Set Associations, Genome-Wide Associations and Protein-Protein Interaction Networks

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Subject Area:
Genetics
Merry-Lynn Noelle McDonald, Manuel Mattheisen, Michael H. Cho, Yang-Yu Liu, Benjamin Harshfield, Craig P. Hersh, Per Bakke, Amund Gulsvik, Christoph Lange, Terri H. Beaty, Edwin K. Silverman, on behalf of the GenKOLS, COPDGene and ECLIPSE study investigators
Journal: Human Heredity
Hum Hered (2015) 78 (3-4): 131–139.
https://doi.org/10.1159/000365589
Published Online: 27 August 2014
..., a method that integrates GWAS results with PPI, to identify COPD disease modules. Results: No gene-sets reached experiment-wide significance in either discovery population. We identified a consensus network of 10 genes identified in modules by integrating GWAS results with PPI that replicated in COPDGene...
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